Antigen Presentation
Event Presentation
- In TAP deficiency, MHC class I-mediated antigen presentation is nearly abolished, leading to a reduced number of CD8+ T cells and hyporesponsive NK cells. The “proteasome, TAP, MHC class I” pathway is crucial for the presentation of self and non-self-peptides to cytotoxic CD8+ T lymphocytes, and also for the presentation of self-motifs to NK cells.
- Extracellular antigens which are taken up by antigen presenting cells will follow, in contrast, an “endosomal digestion – MHC class II” pathway of peptide presentation to naïve T cells or in different settings to a variety of polarized helper T cells or regulatory T cells. This pathway is of major importance in cellular and humoral immune responses.
- Thus, antigen processing and presentation are critically involved in immune homeostasis but also in defense against infectious diseases, in allergic and autoimmune reactions and also in tumor immunology, which means that they are central to many widespread old (in particular infections) and modern (in particular allergies) diseases. They are mostly beneficial during infections, often compromised in tumors which escape the immune response, and inappropriate and exaggerated in allergic reactions.
- The conference therefore aims, in addition to the topic of TAP deficiency, to give an overview of recent developments in fundamental aspects of antigen processing and presentation but also in the context of (i) allergic diseases, (ii) tumor biology and immunotherapy, and (iii) infectious diseases and vaccines. This rather broad spectrum covers most aspects of the problem and the conference is therefore of interest for immunologists, tumor biologists and allergologists, from both the fundamental and the clinical aspects of the topic.
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Read the full Program
15.11.2012: Sessions 1 – 5
Session 1:
Antigen Processing and Presentation: Fundamental Aspects
Session 2
: Human HLA Class I Deficiencies
Session 3:
Antigen Presentation and Allergology
Session 4:
Tumor Biology and Immunotherapy
Session 5:
Keynote Lecture
16.11.2012: Sessions 6 – 8
Session 6:
Immunity and Infectious Diseases
Session 7:
Imaging Techniques in Immunology
Session 8:
Oral Presentation of the Three Best Abstracts (15 minutes/presentation)
PROGRAMME 16 novembre 2012
de 10h30 à 12h15
François HENTGES, Luxembourg
Une mise à jour des connaissances dans:
- 1. les maladies rhumatismales, Spondylarthrite ankylosante, arthrite rhumatoïde, lupus érythémateux systémique, psoriasis, maladie de Behçet
- 2. les maladies auto-immunes d’organes, Diabète insulino-dépendant juvénile, maladie de Basedow, maladie coeliaque, dermatite herpétiforme, syndrome de Sjögren, syndrome de Goodpasture
- 3. les affections neurologiques et oculaires, Sclérose en plaques, narcolepsie, myasthénie grave, rétinochoriodopathie de Birdshot, iridocyclite aigüe
Séance courte de 2 heures spécialement proposée pour permettre à un maximum de cliniciens de profiter de ce congrès
international organisé à Luxembourg.
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| Pr. |
Elliott |
Tim |
Professor of Experimental Medicine, University of Southampton, Southampton, UK |
| Dr |
Malgorzata |
Gosia |
Netherlands Cancer Institute, The Netherlands |
| Pr |
Van Endert |
Peter |
Professor of Immunology, INSERM, Hôpital Necker – Enfants malades, Paris, France |
| Pr. |
Gadola |
Stephan |
Professor of Immunology, University of Southampton, Southampton, UK |
| Pr |
Dogu |
Figen |
Professor of Pediatric Immunology, University of Ankara, Ankara, Turkey |
| Mr |
Sleiman |
Marwan |
PhD Student in the Laboratory of Immunogenetics and Allergology, CRP-Santé, Luxembourg |
| Pr |
Mandelboim |
Ofer |
Professor of Immunology, The Hebrew University, Jerusalem, Israel |
| Pr |
Ferreira |
Fatima |
Professor of Molecular Biology, University of Salzburg, Salzburg, Austria |
| Dr |
Gibbs |
Bernard F |
Senior Lecturer in Immunopharmacology, Medway School of Pharmacy, Kent, UK |
| Dr |
Leonard |
Cathy |
Laboratory of Immunogenetics and Allergology, CRP-Santé, Luxembourg |
| Dr |
Michel |
Tatiana |
Researcher in the Laboratory of Immunogenetics and Allergology, CRP-Santé, Luxembourg |
| Dr |
Hilger |
Christiane |
Senior Researcher in the Laboratory of Immunogenetics and Allergology, CRP-Santé, Luxembourg |
| Pr |
Townsend |
Alain |
PhD, Professor of Molecular Immunology, Weatherall Institute of Molecular Medicine, Oxford, UK |
| Pr |
Seliger |
Barbara |
Professor of Immunology, Martin-Luther-University, Halle-Wittenberg, Germany |
| Pr |
Romero |
Pedro |
Professor of Immunology, The Ludwig Center for Cancer Research, University of Lausanne, Lausanne, Switzerland |
| Pr |
Moretta |
Alessandro |
Professor of Experimental Medicine, University of Genova, Genova, Italy |
| Ms |
Poli |
Aurélie |
Research Engineer and PhD Student in the Laboratory of Immunogenetics and Allergology, CRP-Santé, Luxembourg |
| Dr |
Janji |
Bassam |
Senior Researcher in the Laboratory of Experimental Hemato-Oncology, CRP-Santé, Luxembourg |
| Pr |
Slevogt |
Hortense |
Professor for Host Septomics, Friedrich-Schiller-University, Jena, Germany |
| Dr |
Chalifour |
Anick |
Director of Research and Development, Mymetics Corporation, Epalinges, Switzerland |
| Pr |
Ljunggren |
Hans-Gustaf |
Professor of Infection Medicine, Karolinska Institute, Stockholm, Sweden |
| Mr |
Garcia |
Miguel |
Head of the Flow Cytometry Core Facility, Ecole Polytechnique Fédérale, Lausanne, Switzerland |
| Mr |
Brons |
René |
Head of the Flow Cytometry Core Facility, CRP-Santé, Luxembourg |
PARC HOTEL ALVISSE
Route d’Echternach L-1453 Luxembourg
Phone : (352) 43 56 43 0
Fax : (352) 43 69 03
Room reservation:
Special rates of 87 € per night - The form has to be sent out to the Alvisse Hotel before October 19, 2012 at groups@parc-hotel.lu
Situated at only five minutes from the town centre, the airport, the Kirchberg plateau with the European institutions and LuxExpo, the PARC HOTEL will be happy to welcome you in its natural and relaxing surroundings.
The PARC HOTEL has 320 luxury rooms and serviced apartments, with free WiFi in all rooms; the restaurant “La Véranda” and the bar were completely refurbished, a large relaxation area and a free parking lot for 400 cars are at our guests’ disposal.
Rooms
The PARC HOTEL has 320 luxury rooms and serviced apartments, all of them with free WiFi.
For a prolonged stay in Luxembourg, the PARC HOTEL offers serviced apartments in its main building as well as in its idyllic residence “Le Parc” next to the hotel
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To submit your abstract please refer to the abstract submission form and follow the instructions.
Email the completed form to jacques.zimmer@crp-sante.lu .
Please note that you absolutely have to register for the meeting before submitting your abstract, as submissions without registration will NOT be considered for presentation.
The topic of the abstract should be related to antigen processing or presentation in its fundamental, translational and clinical aspects. For example, abstracts about tumor biology, immunotherapy, allergology, immune deficiencies, infectious diseases and vaccinology are likely to be accepted.
Call for abstracts: extended deadline of October 10th, 2012
Three abstracts will be selected by the Scientific Committee for an oral presentation of 15 minutes during a special “Best Abstract” session on the second day of the meeting. The other accepted abstracts will be presented as posters. The presenting author of the best poster will receive a book price.
Abstract Submission Form
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The conference is sponsored by:
Scientific Sponsor
The Fonds National de la Recherche (FNR)
Since 1999, the FNR has fostered the creation of a pool of knowledge and expertise in Luxembourg and has constantly striven for optimal conditions in national research to bear international comparison. With its current funding activities for public research, the FNR pursues thus a three-fold strategic objective: 1. supporting researchers to build up scientific quality and excellence; 2. contributing to a favorable research environment; 3. promoting scientific culture. The FNR is funding research through various research programmes and grant schemes.
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Gold Sponsors
BD Biosciences, a segment of Becton, Dickinson and Company, is one of the world’s leading businesses focused on bringing innovative tools to life science researchers and clinicians. Principal product lines include flow cytometers and cell sorters, monoclonal antibodies and kits, reagent systems, tools to aid in drug discovery and growing tissue and cells, and diagnostic assays. For more information, please visit www.bdbiosciences.com/eu
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Silver Sponsors
Founded in Luxembourg in 1994, The ‘Fondation Cancer‘ is a non governmental organization with three missions: informing the general public and cancer patients about cancer topics, supporting cancer patients and their family in order to improve their quality of life and funding cancer research. The ‘Fondation Cancer ‘organises every year the ‘Relais pour la Vie’, a national cancer patient’s solidarity event. All this is mainly funded through donations and bequests.
For more information, please visit www.cancer.lu
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eBioscience – an Affymetrix Company is committed to developing and manufacturing high-quality, innovative reagents in an ISO certified facility for both clinical and research environments. As a provider of more than 10,000 products, we empower our customers worldwide to obtain exceptional results by using reagents that offer a new standard of excellence in the areas of innovation, quality and value. eBioscience provides reagents for clinical laboratories as well as research tools for flow cytometry, immunoassay, bioassays, immunoblotting, imaging and microscopy.
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R&D Systems has over 20 year’s experience developing innovative, high quality research reagents. We offer over 18,000 products, developed, manufactured and controlled in our own laboratories.
Products include:
Antibodies
– for neutralisation, cell phenotyping, IHC, Western blot
Flow Cytometry
antibodies, reagents and buffers
Proteins
– cytokines, growth factors, neurotrophic factors, morphogens, chemokines, receptors, and more
Bioactive small molecules
– from Tocris Bioscience
Multiplex assays
– membrane arrays, microplate arrays and Luminex assays
ELISA & ELISpot kits and reagents
For more information go to www.RnDSystems.com
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Miltenyi Biotec develops, manufactures, and sells more than 1,500 products and services for biomedical research; particularly in the fields of cell biology, immunology, regenerative medicine, and molecular biology. In addition to developing cellular therapies, Miltenyi Biotec is the leading provider of tools in this exciting area. Our contract manufacturing divisions manufacture custom biopharmaceuticals, cellular products, and medical devices.
Our mission is to improve scientific understanding and medical progress by providing products and services that advance biomedical research and cellular therapy.
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Bronze Sponsor
Springer – your partner in publishing
Knowledge, information and quality – these are the three things that shape Springer’s activities. We develop, manage and disseminate knowledge – through books, journals and the Internet. We work with leading academics and authors in long-standing loyal partnerships based on mutual trust. With more than 4,300 eBooks currently available in the Biomedical and Life Sciences eBook collection and about 500 Journals our mission is to support daily research work at the best and we are always open to new input.
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Thermo Fisher Scientific Inc. (NYSE: TMO) is the world leader in serving science. Our mission is to enable our customers to make the world healthier, cleaner and safer. With revenues of nearly $11 billion, we have approximately 37,000 employees and serve customers within pharmaceutical and biotech companies, hospitals and clinical diagnostic labs, universities, research institutions and government agencies, as well as in environmental and process control industries. We create value for our key stakeholders through two premier brands, Thermo Scientific and Fisher Scientific, which offer a unique combination of continuous technology development and the most convenient purchasing options. Our products and services help accelerate the pace of scientific discovery, and solve analytical challenges ranging from complex research to routine testing to field applications. Visit www.thermofisher.com .
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Scientific Contact:
Dr. Jacques Zimmer
Senior researcher - CRP-Santé
Phone: (+352) 26 970 260
Information and Communication:
Aurélia Derischebourg
Communication Manager
Phone: (+352) 26 970 893
aurelia.derischebourg@crp-sante.lu
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