Laboratory coordinator : Dr. Brice Appenzeller
University of Luxembourg – LNS Bâtiment des Sciences
162A avenue de la Faïencerie
L-1511 LUXEMBOURG
Phone : + 352 46 66 44-6727
Laboratory of Analytical Human Biomonitoring
The Laboratory of Analytical Human Biomonitoring (LAHB), former Laboratory of Toxicology, is now integrated into the Technology Department/Luxembourg Biomedical Research Resources (LBR2) of CRP-Santé.
Fields of competences of LAHB cover analytical toxicology and development of biomarkers for the assessment of occupational and environmental exposure to organic pollutants and for therapeutic drug monitoring.
Analytical techniques available at LAHB are based on chromatography coupled with tandem mass spectrometry.
The goal of the research activity is development of biomarkers for identification of human exposure to pollutants and for the improvement of knowledge on relationships between exposure and subsequent biological/biochemical disorders.
The development of biomarkers includes research in analytical chemistry using state-of-the-art equipment necessary to reach low levels of molecules present in biological matrices. In order to understand the relationships between the level of exposure and the concentration of molecules in human matrices, we also work on metabolization and incorporation mechanisms of molecules and metabolites in matrices. Disorders associated with exposure are investigated through analysis of specimens from selected human volunteers and experimentation on animal models.
Research includes utilization of biomarkers in epidemiological studies for the determination of reference levels, identification of over-exposed sub-populations and improvement of knowledge on the role of exposure in diseases occurrence.
LAHB actively acts as partner in charge of biological analyses in the framework of national and international epidemiological studies, and provides support for results interpretation, study design and identification of suitable biomarkers.
LAHB provides assistance to researchers within CRP-Santé or through external collaboration with foreign partners for the determination of chemicals (drugs, pollutants, metabolites, etc.) in biological matrices.
LAHB has a recognized expertise in the fields of:
- Human Biomonitoring of environmental and occupational exposure
- Alcohol consumption assessment
- Smoking status assessment (active smoking or exposure to second-hand smoke)
Current Team Members :
Function : Senior Researcher
Phone : +352 466644-6727
Fax : +352 221331
Email : brice.appenzeller@crp-sante.lu
Function : Post-doc Researcher
Email : radu.duca@crp-sante.lu
Function : Researcher
Phone : +352 466644-6730
Fax : +352 221331
Email : nathalie.grova@crp-sante.lu
Function : Technician
Email : emilie.hardy@crp-sante.lu
Function : Research Engineer
Phone : +352 466644-6729
Fax : +352 22-13-31
Email : guillaume.salquebre@crp-sante.lu