To provide its expertise during the preparation of studies in order to determine the design best suited to the research questions. To define the data management methods which guarantee the quality of the results. Supporting teams in the handling of data.
Methodology and Statistics
- The Competence Center for Methodology and Statistics (CCMS) was established in March 2010 in order to meet the methodological and statistical needs of the Department of Public Health and to support the other research departments and laboratories within CRP-Santé. The CCMS further aims to develop contractual public health management and data handling activities for other national and international bodies.
- CCMS also promotes the production of high quality data, which is necessary if the subsequent statistical analysis is to be informative. Expertise is provided during the preparation of studies in order to determine the best suitable design for the research questions asked. Data management methods are also defined, guaranteeing the highest quality of statistical results for each study. For this purpose the Capture System software covers all areas of data management and provides a secure location for clinical data, user rights, and profiles, along with password protection. A full audit trail is put in place for each new study.
- Courses have been provided in statistics in nursing (IFSI), clinical research (IUT), meta-analysis (Roche), and statistical issues in drug development (Royal Statistical Society). A series of statistics notes designed to help medical researchers is in preparation.
The activities of the CCMS include:
- Methodological advice to define research project designs
- Organization of study data in tandem with project managers
- Statistical support for project managers
- Collaboration with external scientists working in fields of mutual interest
- Providing statistical editing support for scientific publications
- Monitoring, editing and updating data management procedures according to international recommendations
- Teaching courses in statistics for healthcare researchers
- Developing and researching statistical methodology of practical relevance to healthcare research
Prof. Stephen Senn (MSc, PhD, CStat) is Head of the CCMS.
As of year-end 2011, CCMS had supported 34 studies during the year (23 of which were in collaboration with the CES). Types of projects included:
- Public health studies investigating health indicators within the Luxembourgish population
- Public health studies based on administrative data
- Observational epidemiological studies
- Interventional epidemiological studies
- Preclinical and clinical studies (including randomized clinical trials)
- Assistance with preclinical study data analysis (proof of principle) for for various laboratories within CRP-Santé
- Collaboration as statistician members of various data-safety monitoring boards
- Various ongoing small projects in collaboration with the pharmaceutical industry
Current Team Members :
Function : Biostatistician
Phone : +352 26970-755
Fax : +352 26970-717
Email : jessica.barre@crp-sante.lu
Function : Biostatistician
Phone : +352 26970-763
Fax : +352 26970-717
Email : valery.bocquet@crp-sante.lu
Function : Biostatistician
Phone : +352 26970-764
Fax : +352 26970-717
Email : nicolas.sauvageot@crp-sante.lu
Function : Head of Competence Center for Methodology and Statistics (CCMS)
Phone : +352 26970-894
Email : stephen.senn@crp-sante.lu
Function : Researcher
Phone : +352 26970-740
Fax : +352 26970-719
Email : michel.vaillant@crp-sante.lu