EVENTS
Structure and dynamics of Heavy metal ATPases and GPCR protein
17/09/2010 9:00 am
- Speaker: Karthik Arumugam
- Language: English
- Location: Bam - 84 Val Fleuri – Strassen
- Contact: andre.steinmetz@crp-sante.lu
Short summary
P1-type ATPases are specific ATP driven pumps which transport soft heavy metals (Cu, Zn, Pb, Cd.) across the cell membranes. These large membrane proteins are difficult to purify and crystallize so that their complete structure is not known. We were interested in the structure and dynamics of the transmembrane part of the Cadmium ATPase (CADA) and the metal binding domains of the human Copper transporting ATPases like Menkes ATPase which takes the metal from the partner metallochaperones.
About the Speaker
Dr. Karthik Arumugam received his PhD in Bioinformatics and Biophysics at the CEA (“Commissariat à l’énergie Atomique”), based in Grenoble (France), and wrote his thesis on the subject of Structure prediction and molecular dynamics simulation in transmembrane protein and GPCR protein. He joined the laboratory of Retrovirology as a post-doctoral researcher in bio-informatics. His work focuses now in the 3-dimensional structure prediction of the GPCR receptors CCR5 and CXCR4 which are the main co-receptors of HIV-1.