2010 - 05 - 05 8th European HIV Drug resistance workshop
The 8th European HIV Drug resistance workshop was held in Sorrento, Italy, from 17-19 March 2010 . The workshop addressed important topics such as mechanisms, clinical implications, epidemiology of drug resistance, resistance to new drugs, resistance technology, managing HIV-HCV co-infection. The Retrovirology Laboratory has presented two oral and three scientific poster presentations.
The European HIV Drug Resistance Workshops have proven very valuable to European researchers and clinicians working in the field of HIV. The workshop has become the place to be to keep abreast of the latest scientific developments in the field of HIV drug resistance and to translate the latest science to daily clinical practice.
Daniel Struck has presented orally the performances of the new CRP subtyping tool "COMET". HIV-1 is classified into phylogenetically defined subtypes that are helpful in surveillance and epidemiological analyses. Daniel Struck has developed a novel approach for the classification of HIV-1 into subtypes based on a context-based modeling. He has shown that the new CRP subtyping tool COMET is as at least as reliable to predict HIV-1 subtype as existing approaches. The performance and scalability of the method allow it to be applied to high throughput sequence analysis. The COMET subtyping tool is available on line in http://comet.retrovirology.lu.
Dr Jean-Claude Karasi has given an oral presentation concerning the drug resistance profiles of Rwandese mothers from the AMATA cohort. The AMATA study has recently shown that breastfeeding under highly active antiretroviral therapy (HAART) in children born to HIV-1 infected mothers is an efficient way of preventing post-natal mother-to-child transmission as compared to formula feeding (Pelletier et al, AIDS 2009). In resource limited settings, the risk of HIV resistance vertical transmission is increasing due to the expanding access of antiretroviral treatment. In this study we have shown that maternal HAART minimize acquired resistance in pregnant women and may represent a successful approach.
The presentations are available on line in http://www.virology-education.com.
Others Retrovirology Laboratory's scientific poster presentations:
The Roche COBAS® AmpliPrep/COBAS® TaqMan® HIV-1, v2.0 and the Abbott RealTime HIV-1 Assays Perform Equally for Quantification of Viral Load in HIV-1 B and non-B Subtypes. Devaux C , Karasi JC, Dziezuk F, Quennery L, Thamke D, Muench- Garthoff S, Kirpach P , Hemmer R , Stockinger H and Schmit JC.
Evaluation of an automated sequence analysis software programme in high-throughput laboratories. Wallis C, Struck D, Bronze M, Denisov G, Schmit C, Rinke de Wit T and Stevens W.
In vitro selection of HIV-2 strains resistant to raltegravir. Triqueneaux P, Perez Bercoff D, Lambert C, Goubau P, Schmit JC and Ruelle J.