NEWS
2011 - 09 - 07 Dr. Karthik Arumugam : expert in bioinformatics, providing high value services which are unique in Luxembourg
Since 2010, Dr. Karthik Arumugam has been working at the Laboratory of Retrovirology-CRP-Santé as an expert in bioinformatics. He has conducted several projects as project investigator at CRP-Santé or in collaboration with different external partners, and has been rewarded several times for outstanding scientific presentations. Dr. Arumugam provides unique, high value bioinformatics services and is open to participate in new research projects in CRP-Santé.
He obtained his PhD in Bioinformatics at the “Commissariat à l'énergie atomique et aux énergies alternatives” (CEA – France) and he has gained outstanding capabilities for several years in the following fields:
1. Development of Algorithms/Software Tools related to Bioinformatics
2. Structure prediction of unknown proteins (Ab initio and Homology Modeling)
3. Quantum Chemistry (parameterization )
4. Modeling, simulation and optimization of the biological complex system.
5. Molecular Modeling & Interaction (Protein, DNA, Ligands , Peptides)
6. Molecular Docking
7. Deriving Structural Motifs for Rational Drug Discovery Research
8. Pharmacophore based drug design
9. De novo drug design
10. Virtual screening
11. Lead Optimization
12. ADME and toxicity prediction
13. Cheminformatics
He has been working on the following projects:
In collaboration with:
- ProSciens , Luxembourg.
- Commissariat à l'énergie atomique et aux énergies alternatives (CEA ), Grenoble, France, Dr. Serge Crouzy, project on P-type ATPases, GPCRs proteins.
- CNRS, Orléans, France, Dr. Norbert Garnier , Project on HIV Coreceptors and Quantum chemistry.
- Université Catholique de Louvain , Belgium, Dr. Jean Ruelle, Project on HIV2 proteins.
- Shri Ramakrishna Engineering College , India, Asst. Prof. V.S Mahendran, Project on Late Embryogenesis Abundant Proteins.
At CRP-Santé with the:
- Laboratory of Retrovirology , Dr. Carole Devaux, project on HCV, HIV Coreceptors, cytochrome P450 protesin.
- Laboratory of Retrovirology , Dr. Sabrina Deroo and Dr. Andy Chevigne, Project on HIV coreceptors and their interaction with the peptides.
- Laboratory of Retrovirology , Dr. Danielle Pérez-Bercoff, project on GP41 and understanding its interaction with T-20..
- Laboratory of Immunogetics and Allergology , Dr. Christiane Hilger, project on Lipocalin and Lipophilins proteins.
- Plant Molecular Biology Laboratory , Dr. Clément Thomas, project on actin-depolymerizing factor and LIM proteins.
- Plant Molecular Biology Laboratory , Dr. Danielle Moes, project on Studying Protein-DNA interaction of LIM protein
Dr. Arumugam has published following publications in 2011:
1. Arabidopsis actin-depolymerizing factors (ADFs) 1 and 9 display antagonist activities, Tholl S, Moreau F, Hoffmann C, Arumugam K , Dieterle M, Moes D, Neumann K, Steinmetz A, Thomas C. 2011 Jun. FEBS Lett. - 585 (12) :1821-7.
2. Identification of a new major dog allergen highly cross-reactive with Fel d 4 in a population of cat and dog sensitized patients, Christiane Hilger, PhD, Kyra Swiontek, MSc, Karthik Arumugam , PhD, Christiane Lehners, MD, François Hentges, MD (communicated)
3. Dynamics and stability of the Metal Binding Domains of the Menkes ATPase. Karthik Arumugam and Serge Crouzy (communicated).
Awards:
Dr Arumugam will receive“The young scientist travel fellowship award” for the 17th International Biophysics Conference which will be held in Beijing, China, 2011 and in order to introduce his work in front of the Noble Laureates. Dr. Arumugam also received the award for his conference presentation entitled “A molecular modeling approach to the evolutionary dynamics of Enfuvirtide Resistance Associated Mutations”, in collaboration with Dr. Carole Devaux, Dr. Jean Claude Schmit, Dr. Danielle Perez Bercoff, at the International workshop on HIV & Hepatitis Virus Drug resistance and curative strategies, in Los Cabos, Mexico, 2011.
We believe that Dr. Arumugam provides unique bioinformatics services which have the potential to add value to currently conducted research at CRP-Santé.
If you wish to collaborate with Dr. Arumugam and to benefit from his competences, or if you need to be supported on a specific contract/project in Bioinformatics, please contact Dr. Arumugam directly at karthik.arumugam@crp-sante.lu