NEWS
2011 - 08 - 03 Heart perturbations of non-cardiovascular drugs
Francisco Azuaje and colleagues at the Laboratory of Cardiovascular Research (LC) have recently characterized the impact of a comprehensive set of drug-target interactions on cardiovascular health. This investigation, published in Nature’s Scientific Reports , expands the understanding of the effect of multiple drugs in the prevention and treatment of cardiovascular disease.
The resulting information resource and discovery methodology can be applied to predict serious adverse cardiac effects of different drugs in patients. Specific connections between non-cardiovascular drugs, such as appetite and smoking suppressants, and major cardiovascular perturbations have been established with this strategy. Moreover, this drug-target interaction network analysis methodology can be extended to other clinical areas. In the near future, LCR will test top computational predictions on a zebrafish model.
The article can be freely accessed at:
http://www.nature.com/srep/2011/110802/srep00052/full/srep00052.html