The laboratory aims to understand the biological mechanisms underlying the initiation and progression of malignant brain tumors , and to identify and characterize novel molecular targets for targeted therapies, including cell and gene therapy, against high grade gliomas.
Norlux Neuro-Oncology Laboratory
The Norlux Neuro-Oncology Laboratory is part of the NorLux Neuro-Oncology network, www.norlux.lu
, a joint network between CRP-Santé, Luxembourg
and the Department of Biomedicine, University of Bergen, Norway
. In 2003 a convention was signed between the two institutions with the aim to foster collaborative research, scientific competence building and staff exchange. A functional laboratory was established at CRP-Santé in 2005/2006.
The laboratory carries out basic and pre-clinical research with a strong translational profile. Our ultimate goal is to generate deliverables that can be tested in the clinical setting to improve current treatment options for brain tumor patients.
The aim of the laboratory is to understand the biological mechanisms underlying the initiation and progression of malignant gliomas and to identify new molecular targets against brain tumors. Based on patient tumor material, the laboratory has developed appropriate animal models to study glioma development in vivo. Using these models we address the identity of cancer-initiating cells, tumour-host interaction, angiogenesis and tumour cell metabolism. We also apply cell micro-encapsulation technology for the delivery of therapeutic proteins in brain diseases.
The laboratory has key competences in basic cell and molecular biology, rodent models, neurosurgery on small animals, in vivo imaging: bioluminescence, fluorescence and magnetic resonance imaging (MRI), cell encapsulation technology, histological techniques, flowcytometry, proteomics analysis and advanced genomic profiling.
The laboratory is active in the following specific research areas:
Head of Laboratory :
Professor : Bergen University
Phone : +352 26970-240:+47 55586352 (Norway)
Email : rolf.bjerkvig@crp-sante.lu
Current Team Members :
Function : PhD Student
Phone : +352 26970-245
Fax : +352 26970-390
Function : Technician
Phone : +352 26970-322
Fax : +352 26970-390
Email : vanessa.barthelemy@crp-sante.lu
Function : Research Engineer
Phone : +352 26970-246
Fax : +352 26970-390
Email : amandine.bernard@crp-sante.lu
Function : PhD Student
Email : swapnil.bhujbal@crp-sante.lu
Function : PhD Student
Phone : +352 26970-286
Fax : +352 26970-390
Email : sebastien.bougnaud@crp-sante.lu
Function : Researcher
Phone : +352 26970-244
Fax : +352 26970-390
Email : anna.golebiewska@crp-sante.lu
Function : Research Engineer
GSM : +352 621227406
Phone : +352 26970-833
Fax : +352 26970-390
Email : olivier.keunen@crp-sante.lu
Function : Research Engineer
Phone : +352 26970-272
Fax : +352 26970-390
Email : anais.oudin@crp-sante.lu
Function : Researcher
Phone : +352 26970-274
Fax : +352 26970-390
Email : daniel.stieber@crp-sante.lu
