Allergic and immune diseases are a major health problem for hundreds of millions of people worldwide.
The aim of the Laboratory of Immunogenetics and Allergology (LIGA) is to strengthen its skills in applied research, to develop competitive basic research and to create an optimal environment for improved diagnosis, prevention and treatment of patients with allergic and immune-mediated diseases. Research is being performed in close collaboration with the national unit of Immunology and Allergology at the CHL.
Laboratory of Immunogenetics and Allergology
The Laboratory of Immunogenetics and Allergology (LIGA), within the Department of Virology, Allergology, and Immunology, utilizes techniques of applied and basic research with the aims of improving the diagnosis, prevention and treatment of patients with allergic and immune-mediated diseases. Research is performed in close collaboration with the national unit of Immunology and Allergology at the Centre Hospitalier de Luxembourg, with activities generously supported by the Ministry of Research and Higher Education and the Fonds National de la Recherche.
Basic research within LIGA focuses on several areas, including:
- Characterization of major animal allergen families
- Analysis of the cellular immune response
- Analysis of the interactions between the nervous and immune systems
- Study of the functional cellular modification in TAP deficiency
Research for improving patient diagnosis and care includes:
- Development of assays to detect sensitization to food and respiratory allergens
- Development of assays to detect and trace allergens and proteins of animal origin
- Transfer of molecular biology techniques to the Centre Hospitalier de Luxembourg
Historically the research unit was born with the help of third party funding, the parents being the clinical unit and the laboratory of Immunology and Allergology of the CHL. Thanks to the modest but continuous support of CRP-Santé, research activities grew continuously over the next fifteen years while relying on the infrastructure of the routine laboratory at the CHL.
Since 2003 there is an important increase in research activities made possible by a financial support becoming substantial, originating to an important part from the Fonds National de la Recherche.
During this period took place a relocation of the laboratory of Immunogenetics and Allergology (LIGA) with different other CRP-Santé research units at the BAM I modular building and a definite integration into the CRP-Santé organization.
The Laboratory of Immunogenics and Allergology (LIGA) is headed by François Hentges MD. Dr. Hentges holds concurrent positions as the Director of the European Federation of Immunogenetics (EFI)-accredited Laboratory at the Centre Hospitalier de Luxembourg and as the President of the Society of Allergy and Clinical Immunology in Luxembourg. He is also a member of several national and international advisory boards. Dr. Hentges and his team have made important contributions towards the bio-molecular characterization of animal allergens, in the field of TAP deficiencies, and in the analysis of certain types of angioedema. Results of these studies have been widely published in international, peer-reviewed scientific journals.