Allergic and immune diseases are a major health problem for hundreds of millions of people worldwide.
The aim of the Laboratory of Immunogenetics and Allergology (LIGA) is to strengthen its skills in applied research, to develop competitive basic research and to create an optimal environment for improved diagnosis, prevention and treatment of patients with allergic and immune-mediated diseases. Research is being performed in close collaboration with the national unit of Immunology and Allergology at the CHL.
Laboratory of Immunogenetics and Allergology
Historically the research unit was born with the help of third party funding, the parents being the clinical unit and the laboratory of Immunology and Allergology of the CHL. Thanks to the modest but continuous support of CRP-Santé, research activities grew continuously over the next fifteen years while relying on the infrastructure of the routine laboratory at the CHL.
Since 2003 there is an important increase in research activities made possible by a financial support becoming substantial, originating to an important part from the Fonds National de la Recherche.
During this period took place a relocation of the laboratory of Immunogenetics and Allergology (LIGA) with different other CRP-Santé research units at the BAM I modular building and a definite integration into the CRP-Santé organization.
In its scientific strategies the LIGA aims at performing high quality basic research focusing on the:
- Characterization at the protein and DNA-level of three major animal allergen families: lipocalins, serum albumins and parvalbumins.
- Analysis of the cellular immune response, including cellular regulatory mechanisms to selected allergens belonging to these protein families.
- Analyzing interactions between the nervous system and the immune system by studying the effects of several neurotrophins on natural killer cells.
- Study of the functional cellular modification found in TAP deficiency.
Secondly the laboratory applies its research potential at improving patient diagnosis and care. This implies:
- Development of reagents for in vitro detection of patient sensitization to food and respiratory allergens.
- Development of protein and DNA reagents to detect and trace animal allergens and proteins of animal origin.
- Technology transfer to the laboratory of Immunology and Allergology at the CHL in molecular biology techniques.
Head of Laboratory :
Phone : +352 26970-250:+352 4411-2219 (CHL)
Fax : +352 26970-390: +352 441255
Email : francois.hentges@crp-sante.lu
Current Team Members :
Function : Technician
Phone : +352 26970-327
Fax : +352 26970-390
Email : caroline.davril@crp-sante.lu
Function : Technician
Phone : +352 26970-327:+352 26970-819
Fax : +352 26970390
Email : olivia.domingues@crp-sante.lu
Function : Technician
Phone : +352 26970-327
Fax : +352 26970-390
Email : thorsten.graf@crp-sante.lu
Function : Senior Researcher
Phone : +352 26970-258
Fax : +352 26970-390
Email : christiane.hilger@crp-sante.lu
Function : Research Engineer
Phone : +352 26970-254
Fax : +352 26970-277
Email : stephanie.kler@crp-sante.lu
Function : Researcher
Phone : +352 26970-335
Fax : +352 26970-390
Email : annette.kuehn@crp-sante.lu
Function : Technician
Phone : +352 26970-254
Fax : +352 26970-390
Email : delphine.lentz@crp-sante.lu
Function : Researcher
Phone : +352 26970-259
Fax : +352 26970-277
Email : cathy.leonard@crp-sante.lu
Function : PhD Student
Email : marion.mauffray@crp-sante.lu
Function : Researcher
Phone : +352 26970-264
Fax : +352 26970-390
Email : tatiana.michel@crp-sante.lu
Function : Research Engineer
Phone : +352 26970-323
Fax : +352 26970-390
Email : aurelie.poli@crp-sante.lu
Function : Technician
Phone : +352 26970-327
Fax : +352 26970-390
Email : tanja.scheuermann@crp-sante.lu
Function : Research Engineer
Phone : +352 26970-327
Fax : +352 26970390
Email : kyra.swiontek@crp-sante.lu
Function : Senior Researcher
Phone : +352 26970-260
Fax : +352 26970-390
Email : jacques.zimmer@crp-sante.lu
