The laboratory of Retrovirology performs fundamental and applied research in the field of chronic viral infections (HIV, HBV, HCV). The activities of the laboratory focus on two research domains, which interact closely: immuno-virology and clinical virology.
Laboratory of Retrovirology
The Laboratory of Retrovirology focuses on basic and applied research of chronic viral infections, specifically HIV, hepatitis B virus (HBV) and hepatitis C virus (HCV) and the laboratory is working in close collaboration with the National Service of Infectious Diseases at the Centre Hospitalier of Luxembourg (CHL).
Research in the Laboratory of Retrovirology is divided amongst two closely intertwined areas: immunovirology and clinical virology.
The immunovirology division has focused attention on the study of 1) viral and host factors in virus entry, with the aim of identifying novel diagnostic tools and therapeutic lead compounds and, 2) humoral immune responses during HIV infection, which may lead to the development of a multi-epitope vaccine.
Areas of focus within the clinical virology unit include:
- Transmission networks and dynamics of epidemics caused by HIV and HCV in Luxembourg
- Primary transmitted and secondary resistance to antiretroviral therapy (HIV-1,HIV-2)
- Clinical implications of viral and host factors involved in HIV-1 entry
- Collaborations with African countries
Routine clinical activities are generously financed by the Ministry of Health, and members of the Retrovirology laboratory may be employees of CRP- Santéor are employed by the Centre Hospitalier de Luxembourg and contribute part time to research.
> Immuno-virology research unit
> Clinical virology research unit
Chronic viral infections caused by HIV and HCV are an ever-growing public health problem in Luxembourg as in the rest of the world. The Laboratory of Retrovirology was founded in 1989 as the national reference laboratory for HIV and is working in close relationship with the National Department of Infectious Diseases. Besides routine clinical activities financed by the Ministry of Health, the Laboratory of Retrovirology has developed clinically oriented biomedical research in the field of chronic viral infections. The activities of the laboratory focus on two research domains, which interact closely: immuno-virology and clinical virology.
Our bioinformatics team has developed tools to support HIV research projects:
- the automated sequence analysis software ART-A for HIV and developed within the ART-A network project
- the HIV subtyping tool COMET
Our HIV research is supported by grants from the "Fondation Recherche sur le SiDA". Tax-deducible donations to the foundation can be made on the bank accounts:
BIC CCPLLULL IBAN LU88 1111 0877 7890 0000
BIC BGLLLULL IBAN LU92 0030 4314 3109 0000
BIC BILLLULL IBAN LU20 0021 1072 3090 0000,
under the label "support for the Laboratory of Retrovirology/CRP-Santé".