The laboratory aims to understand the biological mechanisms underlying the initiation and progression of malignant brain tumors , and to identify and characterize novel molecular targets for targeted therapies, including cell and gene therapy, against high grade gliomas.
Norlux Neuro-Oncology Laboratory
Headed by Dr. Simone P. Niclou, the NorLux Neuro-Oncology Laboratory has developed animal models to study glioma development in vivo, and has applied cell micro-encapsulation technology for the delivery of therapeutic proteins in brain diseases. The laboratory has key competences in basic cell and molecular biology, rodent models, neurosurgery on small animals, and cutting-edge in vivo imaging techniques. Major research topics include, anti-angiogenic treatment against brain tumors, tumor heterogeneity and adaptability, and tumor cell metabolism. Through CRP-Santé’s Competence Center platforms and collaborating national and international organizations, the laboratory has access to cutting-edge technologies for genomics, proteomics, and metabolomics profiling.
The NorLux Neuro-Oncology Laboratory carries out basic and pre-clinical research with an emphasis in two major areas: 1) understanding the biological mechanisms underlying the initiation and progression of malignant gliomas and, 2) identification of novel molecular targets for therapies against brain tumors. The ultimate goal of the laboratory is to improve current treatment options for patients with brain tumors.
The laboratory is active in the following specific research areas:
- Role of Cancer Stem Cells in Brain Tumour Initiation and Progression
- Identifying Molecular Targets on Human Glioblastoma
- Mechanisms of anti-angiogenic treatment in malignant gliomas
- Application of Cell Microencapsulation Technology to the Treatment of Brain Disorders
The NorLux Neuro-Oncology Laboratory, within the Department of Oncology, is a division of the NorLux Neuro-Oncology network, a joint network between CRP-Santé and the Department of Biomedicine at the University of Bergen, in Norway. The aim of this joint venture is to foster collaborative research, scientific competence building and staff exchange.
Simone P. Niclou , PhD, is Head of the Norlux Neuro-Oncology Laboratory and Head of the Animal Facility at CRP-Santé. Dr. Niclou is a member of the Scientific Advisory Board of the European Association of Neuro-Oncology (EANO) and serves as a representative of Luxembourg, as Council Member of the European Association for Cancer Research (EACR). Dr. Niclou is a regular invited speaker at numerous international scientific conferences, and she has been a guest lecturer at national and international universities. Dr. Niclou is the recipient of numerous research grants and publishes her work in high impact international peer-reviewed scientific journals.