The laboratory aims to understand the biological mechanisms underlying the initiation and progression of malignant brain tumors , and to identify and characterize novel molecular targets for targeted therapies, including cell and gene therapy, against high grade gliomas.
IDENTIFYING MOLECULAR TARGETS ON HUMAN GLIOBLASTOMA
Glioblastoma is a highly heterogeneous cancer both at the genetic and phenotypic level. This diversity needs to be taken into account in the design of novel therapeutic strategies. In this project we apply high throughput screening methods, including transcriptomics and whole genome shRNA libraries, to identify novel molecular targets against malignant glioma. In addition we use array comparative genomic hybridization (aCGH) to define the genetic profile of glioblastoma samples and to correlate this with their phenotypic appearance.
