Dirk Brenner

Latest publications

Survival of the fittest: Cancer challenges T cell metabolism.

  • Experimental and Molecular Immunology
  • Immune Systems Biology
October 24, 2017
2017 Oct. Cancer Lett. [Epub ahead of print].
By:
  • Franchina DG
  • He F
  • Brenner D.

MALT1 is an intrinsic regulator of regulatory T cells.

  • Experimental and Molecular Immunology
July 01, 2017
2017 Jul. Cell Death Differ.24(7):1214-1223. Epub 2015 Sep 25.
By:
  • Brustle A
  • Brenner D
  • Knobbe-Thomsen CB
  • Cox M
  • Lang PA
  • Lang KS
  • Mak TW.

Glutathione primes T cell metabolism for inflammation.

  • Experimental and Molecular Immunology
  • Allergy and Clinical Immunology
April 18, 2017
2017 Apr. Immunity.46(4):675-689.
By:
  • Mak TW
  • Grusdat M
  • Duncan GS
  • Dostert C
  • Nonnenmacher Y
  • Cox M
  • Binsfeld C
  • Hao Z
  • Brustle A
  • Itsumi M
  • Jager C
  • Chen Y
  • Pinkenburg O
  • Camara B
  • Ollert M
  • Bindslev-Jensen C
  • Vasiliou V
  • Gorrini C
  • Lang PA
  • Lohoff M
  • Harris IS
  • Hiller K
  • Brenner D.

K48-linked KLF4 ubiquitination by E3 ligase Mule controls T-cell proliferation and cell cycle progression.

  • Experimental and Molecular Immunology
January 13, 2017
2017 Jan. Nat Commun.8:14003.
By:
  • Hao Z
  • Sheng Y
  • Duncan GS
  • Li WY
  • Dominguez C
  • Sylvester J
  • Su YW
  • Lin GH
  • Snow BE
  • Brenner D
  • You-Ten A
  • Haight J
  • Inoue S
  • Wakeham A
  • Elford A
  • Hamilton S
  • Liang Y
  • Zuniga-Pflucker JC
  • He HH
  • Ohashi PS
  • Mak TW.

RAIDD Mediates TLR3 and IRF7 Driven Type I Interferon Production.

  • Experimental and Molecular Immunology
September 08, 2016
2016 Sep. Cell Physiol Biochem.39(4):1271-80. Epub 2016 Sep 8.
By:
  • Maney SK
  • Xu HC
  • Huang J
  • Pandyra AA
  • Ehlting C
  • Aguilar-Valenzuela R
  • Pozdeev VI
  • McIlwain DR
  • Zimmermann A
  • Bode JG
  • Hengel H
  • Kirschning CJ
  • Kim IR
  • Hiscott J
  • Brenner D
  • Haussinger D
  • Ohashi PS
  • Mak TW
  • Lang KS
  • Lang PA.

TNF and ROS crosstalk in inflammation.

  • Experimental and Molecular Immunology
April 01, 2016
2016 Apr. Trends Cell Biol.26(4):249-61. Epub 2016 Jan 12.
By:
  • Blaser H
  • Dostert C
  • Mak TW
  • Brenner D.

Idh1 protects murine hepatocytes from endotoxin-induced oxidative stress by regulating the intracellular NADP(+)/NADPH ratio.

  • Experimental and Molecular Immunology
November 01, 2015
2015 Nov. Cell Death Differ.22(11):1837-45. Epub 2015 Apr 17.
By:
  • Itsumi M
  • Inoue S
  • Elia AJ
  • Murakami K
  • Sasaki M
  • Lind EF
  • Brenner D
  • Harris IS
  • Chio
  • II
  • Afzal S
  • Cairns RA
  • Cescon DW
  • Elford AR
  • Ye J
  • Lang PA
  • Li WY
  • Wakeham A
  • Duncan GS
  • Haight J
  • You-Ten A
  • Snow B
  • Yamamoto K
  • Ohashi PS
  • Mak TW.

Antigen receptor-mediated depletion of FOXP3 in induced regulatory T-lymphocytes via PTPN2 and FOXO1.

  • Experimental and Molecular Immunology
October 13, 2015
2015 Oct. Nat Commun.6:8576.
By:
  • Bothur E
  • Raifer H
  • Haftmann C
  • Stittrich AB
  • Brustle A
  • Brenner D
  • Bollig N
  • Bieringer M
  • Kang CH
  • Reinhard K
  • Camara B
  • Huber M
  • Visekruna A
  • Steinhoff U
  • Repenning A
  • Bauer UM
  • Sexl V
  • Radbruch A
  • Sparwasser T
  • Mashreghi MF
  • Wah Mak T
  • Lohoff M.

Regulation of tumour necrosis factor signalling: live or let die.

  • Experimental and Molecular Immunology
May 26, 2015
2015 May. Nat Rev Immunol.15(6):362-74.
By:
  • Brenner D
  • Blaser H
  • Mak TW.

Deficiency of MALT1 paracaspase activity results in unbalanced regulatory and effector T and B cell responses leading to multiorgan inflammation.

  • Experimental and Molecular Immunology
April 15, 2015
2015 Apr. J Immunol.194(8):3723-34. Epub 2015 Mar 11.
By:
  • Bornancin F
  • Renner F
  • Touil R
  • Sic H
  • Kolb Y
  • Touil-Allaoui I
  • Rush JS
  • Smith PA
  • Bigaud M
  • Junker-Walker U
  • Burkhart C
  • Dawson J
  • Niwa S
  • Katopodis A
  • Nuesslein-Hildesheim B
  • Weckbecker G
  • Zenke G
  • Kinzel B
  • Traggiai E
  • Brenner D
  • Brustle A
  • St Paul M
  • Zamurovic N
  • McCoy KD
  • Rolink A
  • Regnier CH
  • Mak TW
  • Ohashi PS
  • Patel DD
  • Calzascia T.

Energy-sensitive regulation of Na+/K+-ATPase by Janus kinase 2.

  • Experimental and Molecular Immunology
February 15, 2015
2015 Feb. Am J Physiol Cell Physiol.306(4):C374-84. Epub 2013 Dec 4.
By:
  • Bhavsar SK
  • Hosseinzadeh Z
  • Brenner D
  • Honisch S
  • Jilani K
  • Liu G
  • Szteyn K
  • Sopjani M
  • Mak TW
  • Shumilina E
  • Lang F.

Glutathione and thioredoxin antioxidant pathways synergize to drive cancer initiation and progression.

  • Experimental and Molecular Immunology
February 09, 2015
2015 Feb. Cancer Cell.27(2):211-22. Epub 2015 Jan 22.
By:
  • Harris IS
  • Treloar AE
  • Inoue S
  • Sasaki M
  • Gorrini C
  • Lee KC
  • Yung KY
  • Brenner D
  • Knobbe-Thomsen CB
  • Cox MA
  • Elia A
  • Berger T
  • Cescon DW
  • Adeoye A
  • Brustle A
  • Molyneux SD
  • Mason JM
  • Li WY
  • Yamamoto K
  • Wakeham A
  • Berman HK
  • Khokha R
  • Done SJ
  • Kavanagh TJ
  • Lam CW
  • Mak TW.

Autophagy-independent functions of UVRAG are essential for peripheral naive T-cell homeostasis.

  • Experimental and Molecular Immunology
January 27, 2015
2015 Jan. Proc Natl Acad Sci U S A.112(4):1119-24. Epub 2015 Jan 12.
By:
  • Afzal S
  • Hao Z
  • Itsumi M
  • Abouelkheer Y
  • Brenner D
  • Gao Y
  • Wakeham A
  • Hong C
  • Li WY
  • Sylvester J
  • Gilani SO
  • Brustle A
  • Haight J
  • You-Ten AJ
  • Lin GH
  • Inoue S
  • Mak TW.

Toso regulates differentiation and activation of inflammatory dendritic cells during persistence-prone virus infection.

  • Experimental and Molecular Immunology
January 01, 2015
2015 Jan. Cell Death Differ.22(1):164-73. Epub 2014 Sep 26.
By:
  • Lang PA
  • Meryk A
  • Pandyra AA
  • Brenner D
  • Brustle A
  • Xu HC
  • Merches K
  • Lang F
  • Khairnar V
  • Sharma P
  • Funkner P
  • Recher M
  • Shaabani N
  • Duncan GS
  • Duhan V
  • Homey B
  • Ohashi PS
  • Haussinger D
  • Knolle PA
  • Honke N
  • Mak TW
  • Lang KS.

Toso controls encephalitogenic immune responses by dendritic cells and regulatory T cells.

  • Experimental and Molecular Immunology
January 21, 2014
2014 Jan. Proc Natl Acad Sci U S A.111(3):1060-5. Epub 2014 Jan 7.
By:
  • Brenner D
  • Brustle A
  • Lin GH
  • Lang PA
  • Duncan GS
  • Knobbe-Thomsen CB
  • St Paul M
  • Reardon C
  • Tusche MW
  • Snow B
  • Hamilton SR
  • Pfefferle A
  • Gilani SO
  • Ohashi PS
  • Lang KS
  • Mak TW.

Cellular senescence or EGFR signaling induces Interleukin 6 (IL-6) receptor expression controlled by mammalian target of rapamycin (mTOR).

  • Experimental and Molecular Immunology
November 01, 2013
2013 Nov. Cell Cycle.12(21):3421-32. Epub 2013 Sep 18.
By:
  • Garbers C
  • Kuck F
  • Aparicio-Siegmund S
  • Konzak K
  • Kessenbrock M
  • Sommerfeld A
  • Haussinger D
  • Lang PA
  • Brenner D
  • Mak TW
  • Rose-John S
  • Essmann F
  • Schulze-Osthoff K
  • Piekorz RP
  • Scheller J.

BRCA1 interacts with Nrf2 to regulate antioxidant signaling and cell survival.

  • Experimental and Molecular Immunology
July 29, 2013
2013 Jul. J Exp Med.210(8):1529-44. Epub 2013 Jul 15.
By:
  • Gorrini C
  • Baniasadi PS
  • Harris IS
  • Silvester J
  • Inoue S
  • Snow B
  • Joshi PA
  • Wakeham A
  • Molyneux SD
  • Martin B
  • Bouwman P
  • Cescon DW
  • Elia AJ
  • Winterton-Perks Z
  • Cruickshank J
  • Brenner D
  • Tseng A
  • Musgrave M
  • Berman HK
  • Khokha R
  • Jonkers J
  • Mak TW
  • Gauthier ML.

Reactive oxygen species delay control of lymphocytic choriomeningitis virus.

  • Experimental and Molecular Immunology
April 01, 2013
2013 Apr. Cell Death Differ.20(4):649-58. Epub 2013 Jan 18.
By:
  • Lang PA
  • Xu HC
  • Grusdat M
  • McIlwain DR
  • Pandyra AA
  • Harris IS
  • Shaabani N
  • Honke N
  • Maney SK
  • Lang E
  • Pozdeev VI
  • Recher M
  • Odermatt B
  • Brenner D
  • Haussinger D
  • Ohashi PS
  • Hengartner H
  • Zinkernagel RM
  • Mak TW
  • Lang KS.

Reduced type I interferon production by dendritic cells and weakened antiviral immunity in patients with Wiskott-Aldrich syndrome protein deficiency.

  • Experimental and Molecular Immunology
March 01, 2013
2013 Mar. J Allergy Clin Immunol.131(3):815-24. Epub 2012 Nov 6.
By:
  • Lang PA
  • Shaabani N
  • Borkens S
  • Honke N
  • Scheu S
  • Booth S
  • Brenner D
  • Meryk A
  • Barthuber C
  • Recher M
  • Mak TW
  • Ohashi PS
  • Haussinger D
  • Griffiths GM
  • Thrasher AJ
  • Bouma G
  • Lang KS.

Lymphocyte-derived ACh regulates local innate but not adaptive immunity.

  • Experimental and Molecular Immunology
January 22, 2013
2013 Jan. Proc Natl Acad Sci U S A.110(4):1410-5. Epub 2013 Jan 7.
By:
  • Reardon C
  • Duncan GS
  • Brustle A
  • Brenner D
  • Tusche MW
  • Olofsson PS
  • Rosas-Ballina M
  • Tracey KJ
  • Mak TW.