Manuel Counson

Latest publications

Development of Mimokines, chemokine N terminus-based CXCR4 inhibitors optimized by phage display and rational design.

  • Molecular Signalling and Virus-Host Interactions
  • HIV Clinical and Translational Research
March 23, 2018
2018 Mar. J Leukoc Biol.(Development of Mimokines, chemokine N terminus-based CXCR4 inhibitor). [Epub ahead of print].
By:
  • Fievez V
  • Szpakowska M
  • Mosbah A
  • Arumugam K
  • Mathu J
  • Counson M
  • Beaupain N
  • Seguin-Devaux C
  • Deroo S
  • Baudy-Floc'h M
  • Chevigne A.

Mutational analysis of the extracellular disulphide bridges of the atypical chemokine receptor ACKR3/CXCR7 uncovers multiple binding and activation modes for its chemokine and endogenous non-chemokine agonists.

  • Molecular Signalling and Virus-Host Interactions
March 09, 2018
2018 Mar. Biochem Pharmacol. [Epub ahead of print].
By:
  • Szpakowska M
  • Meyrath M
  • Reynders N
  • Counson M
  • Hanson J
  • Steyaert J
  • Chevigne A.

Different contributions of chemokine N-terminal features attest to a different ligand binding mode and a bias towards activation of ACKR3/CXCR7 compared with CXCR4 and CXCR3.

  • Molecular Signalling and Virus-Host Interactions
December 22, 2017
2017 Dec. Br J Pharmacol. [Epub ahead of print].
By:
  • Szpakowska M
  • Nevins AM
  • Meyrath M
  • Rhainds D
  • D'Huys T
  • Guite-Vinet F
  • Dupuis N
  • Gauthier PA
  • Counson M
  • Kleist A
  • St-Onge G
  • Hanson J
  • Schols D
  • Volkman BF
  • Heveker N
  • Chevigne A.

Human herpesvirus 8-encoded chemokine vCCL2/vMIP-II is an agonist of the atypical chemokine receptor ACKR3/CXCR7.

  • Molecular Signalling and Virus-Host Interactions
August 15, 2016
2016 Aug. Biochem Pharmacol.114:14-21. Epub 2016 May 27.
By:
  • Szpakowska M
  • Dupuis N
  • Baragli A
  • Counson M
  • Hanson J
  • Piette J
  • Chevigne A.

Isolation of an HIV-1 neutralizing peptide mimicking the CXCR4 and CCR5 surface from the heavy-chain complementary determining region 3 repertoire of a viremic controller.

  • Molecular Signalling and Virus-Host Interactions
  • Immune Systems Biology
  • HIV Clinical and Translational Research
January 28, 2016
2016 Jan. AIDS.30(3):377-82.
By:
  • Chevigne A
  • Delhalle S
  • Counson M
  • Beaupain N
  • Rybicki A
  • Verschueren C
  • Staub T
  • Schmit JC
  • Seguin-Devaux C
  • Deroo S.

Neutralising properties of peptides derived from CXCR4 extracellular loops towards CXCL12 binding and HIV-1 infection.

  • Molecular Signalling and Virus-Host Interactions
May 01, 2014
2014 May. Biochim Biophys Acta-Mol Cell Res.1843(5):1031-41(5):1031-41. Epub 2014 Jan 27.
By:
  • Chevigne A
  • Fievez V
  • Szpakowska M
  • Fischer A
  • Counson M
  • Plesseria JM
  • Schmit JC
  • Deroo S.

Selection of a CXCR4 antagonist from a human heavy chain CDR3-derived phage library.

  • Molecular Signalling and Virus-Host Interactions
August 01, 2011
2011 Aug. FEBS J.278(16):2867-78. Epub 2011 Jun 27.
By:
  • Chevigne A
  • Fischer A
  • Mathu J
  • Counson M
  • Beaupain N
  • Plesseria JM
  • Schmit JC
  • Deroo S.