Michel Mittelbronn

Latest publications

Pre- and early postoperative GFAP serum levels in glioma and brain metastases.

  • Luxembourg Center of Neuropathology
September 01, 2018
2018 Sep. J Neurooncol.139(3):541-546. Epub 2018 May 24.
By:
  • Baumgarten P
  • Quick-Weller J
  • Gessler F
  • Wagner M
  • Tichy J
  • Forster MT
  • Foerch C
  • Seifert V
  • Mittelbronn M
  • Senft C.

Microglia in health and disease: A unique immune cell population. (Book)

  • NORLUX Neuro-Oncology Laboratory
  • Luxembourg Center of Neuropathology
September 01, 2018
2018 Sep. Michelucci A, Mittelbronn M and Gomez-Nicola D, eds. Lausanne: Frontiers Media, 2018. 106 p. (Frontiers Research topic). ISBN 978-2-88945-601-7.
By:
  • Michelucci A
  • Mittelbronn M
  • Gomez-Nicola D
  • et al.

EGFL7 enhances surface expression of integrin alpha5beta1 to promote angiogenesis in malignant brain tumors.

  • NORLUX-Glioma Biology
  • In vivo imaging facility
  • Luxembourg Center of Neuropathology
September 01, 2018
2018 Sep. EMBO Mol Med.10(9).
By:
  • Dudvarski Stankovic N
  • Bicker F
  • Keller S
  • Jones DT
  • Harter PN
  • Kienzle A
  • Gillmann C
  • Arnold P
  • Golebiewska A
  • Keunen O
  • Giese A
  • von Deimling A
  • Bauerle T
  • Niclou SP
  • Mittelbronn M
  • Ye W
  • Pfister SM
  • Schmidt MH.

Microglia in health and disease: a unique immune cell population.

  • NORLUX-Glioma Biology
  • Luxembourg Center of Neuropathology
August 15, 2018
2018 Aug. Front Immunol.9:1779.
By:
  • Michelucci A
  • Mittelbronn M
  • Gomez-Nicola D.

Adjuvant therapy using mistletoe containing drugs boosts the T-cell-mediated killing of glioma cells and prolongs the survival of glioma-bearing mice.

  • Luxembourg Center of Neuropathology
July 24, 2018
2018 Jul. Evid Based Complement Alternat Med.2018:3928572.
By:
  • Schotterl S
  • Huber SM
  • Lentzen H
  • Mittelbronn M
  • Naumann U.

AT 101 induces early mitochondrial dysfunction and HMOX1 (heme oxygenase 1) to trigger mitophagic cell death in glioma cells.

  • Luxembourg Center of Neuropathology
July 21, 2018
2018 Jul. Autophagy.14(10):1693-1709. Epub 2018 Jul 21.
By:
  • Meyer N
  • Zielke S
  • Michaelis JB
  • Linder B
  • Warnsmann V
  • Rakel S
  • Osiewacz HD
  • Fulda S
  • Mittelbronn M
  • Munch C
  • Behrends C
  • Kogel D.

Pericytes/vessel-associated mural cells (VAMCs) are the major source of key epithelial-mesenchymal transition (EMT) factors SLUG and TWIST in human glioma.

  • Luxembourg Center of Neuropathology
  • NORLUX-Glioma Biology
May 08, 2018
2018 May. Oncotarget.9(35):24041-24053.
By:
  • Mader L
  • Blank AE
  • Capper D
  • Jansong J
  • Baumgarten P
  • Wirsik NM
  • Zachskorn C
  • Ehlers J
  • Seifert M
  • Klink B
  • Liebner S
  • Niclou S
  • Naumann U
  • Harter PN
  • Mittelbronn M.

A Chimeric Antibody against ACKR3/CXCR7 in Combination with TMZ Activates Immune Responses and Extends Survival in Mouse GBM Models.

  • Luxembourg Center of Neuropathology
May 02, 2018
2018 May. Mol Ther.26(5):1354-1365. Epub 2018 Mar 6.
By:
  • Salazar N
  • Carlson JC
  • Huang K
  • Zheng Y
  • Oderup C
  • Gross J
  • Jang AD
  • Burke TM
  • Lewen S
  • Scholz A
  • Huang S
  • Nease L
  • Kosek J
  • Mittelbronn M
  • Butcher EC
  • Tu H
  • Zabel BA.

DNA methylation-based classification of central nervous system tumours.

  • NORLUX-Glioma Biology
  • Luxembourg Center of Neuropathology
March 22, 2018
2018 Mar. Nature.555(7697):469-474. Epub 2018 Mar 14.
By:
  • Capper D
  • Jones DTW
  • Sill M
  • Hovestadt V
  • Schrimpf D
  • Sturm D
  • Koelsche C
  • Sahm F
  • Chavez L
  • Reuss DE
  • Kratz A
  • Wefers AK
  • Huang K
  • Pajtler KW
  • Schweizer L
  • Stichel D
  • Olar A
  • Engel NW
  • Lindenberg K
  • Harter PN
  • Braczynski AK
  • Plate KH
  • Dohmen H
  • Garvalov BK
  • Coras R
  • Holsken A
  • Hewer E
  • Bewerunge-Hudler M
  • Schick M
  • Fischer R
  • Beschorner R
  • Schittenhelm J
  • Staszewski O
  • Wani K
  • Varlet P
  • Pages M
  • Temming P
  • Lohmann D
  • Selt F
  • Witt H
  • Milde T
  • Witt O
  • Aronica E
  • Giangaspero F
  • Rushing E
  • Scheurlen W
  • Geisenberger C
  • Rodriguez FJ
  • Becker A
  • Preusser M
  • Haberler C
  • Bjerkvig R
  • Cryan J
  • Farrell M
  • Deckert M
  • Hench J
  • Frank S
  • Serrano J
  • Kannan K
  • Tsirigos A
  • Bruck W
  • Hofer S
  • Brehmer S
  • Seiz-Rosenhagen M
  • Hanggi D
  • Hans V
  • Rozsnoki S
  • Hansford JR
  • Kohlhof P
  • Kristensen BW
  • Lechner M
  • Lopes B
  • Mawrin C
  • Ketter R
  • Kulozik A
  • Khatib Z
  • Heppner F
  • Koch A
  • Jouvet A
  • Keohane C
  • Muhleisen H
  • Mueller W
  • Pohl U
  • Prinz M
  • Benner A
  • Zapatka M
  • Gottardo NG
  • Driever PH
  • Kramm CM
  • Muller HL
  • Rutkowski S
  • von Hoff K
  • Fruhwald MC
  • Gnekow A
  • Fleischhack G
  • Tippelt S
  • Calaminus G
  • Monoranu CM
  • Perry A
  • Jones C
  • Jacques TS
  • Radlwimmer B
  • Gessi M
  • Pietsch T
  • Schramm J
  • Schackert G
  • Westphal M
  • Reifenberger G
  • Wesseling P
  • Weller M
  • Collins VP
  • Blumcke I
  • Bendszus M
  • Debus J
  • Huang A
  • Jabado N
  • Northcott PA
  • Paulus W
  • Gajjar A
  • Robinson GW
  • Taylor MD
  • Jaunmuktane Z
  • Ryzhova M
  • Platten M
  • Unterberg A
  • Wick W
  • Karajannis MA
  • Mittelbronn M
  • Acker T
  • Hartmann C
  • Aldape K
  • Schuller U
  • Buslei R
  • Lichter P
  • Kool M
  • Herold-Mende C
  • Ellison DW
  • Hasselblatt M
  • Snuderl M
  • Brandner S
  • Korshunov A
  • von Deimling A
  • Pfister SM.

New MR perfusion features in primary central nervous system lymphomas: pattern and prognostic impact.

  • Luxembourg Center of Neuropathology
March 01, 2018
2018 Mar. J Neurol.265(3):647-658. Epub 2018 Jan 30.
By:
  • Blasel S
  • Vorwerk R
  • Kiyose M
  • Mittelbronn M
  • Brunnberg U
  • Ackermann H
  • Voss M
  • Harter PN
  • Hattingen E.

CD74 regulates complexity of tumor cell HLA class II peptidome in brain metastasis and is a positive prognostic marker for patient survival.

  • Luxembourg Center of Neuropathology
  • Bioinformatics and Modelling
March 01, 2018
2018 Mar. Acta Neuropathol Commun.6(1):18.
By:
  • Zeiner PS
  • Zinke J
  • Kowalewski DJ
  • Bernatz S
  • Tichy J
  • Ronellenfitsch MW
  • Thorsen F
  • Berger A
  • Forster MT
  • Muller A
  • Steinbach JP
  • Beschorner R
  • Wischhusen J
  • Kvasnicka HM
  • Plate KH
  • Stefanovic S
  • Weide B
  • Mittelbronn M
  • Harter PN.

An advanced glioma cell invasion assay based on organotypic brain slice cultures.

  • Luxembourg Center of Neuropathology
January 30, 2018
2018 Jan. BMC Cancer.18(1):103.
By:
  • Eisemann T
  • Costa B
  • Strelau J
  • Mittelbronn M
  • Angel P
  • Peterziel H.

Autophagosomal Content Profiling Reveals an LC3C-Dependent Piecemeal Mitophagy Pathway.

  • Luxembourg Center of Neuropathology
November 16, 2017
2017 Nov. Mol Cell.68(4):786-796.e6.
By:
  • Le Guerroue F
  • Eck F
  • Jung J
  • Starzetz T
  • Mittelbronn M
  • Kaulich M
  • Behrends C.

ASA404, a vascular disrupting agent, as an experimental treatment approach for brain tumors.

  • Luxembourg Center of Neuropathology
October 11, 2017
2017 Oct. Oncol Lett.14(5):5443-5451. Epub 2017 Aug 28.
By:
  • Bahr O
  • Gross S
  • Harter PN
  • Kirches E
  • Mawrin C
  • Steinbach JP
  • Mittelbronn M.

Biopsies of pediatric brainstem lesions display low morbidity but strong impact on further treatment decisions.

  • Luxembourg Center of Neuropathology
October 01, 2017
2017 Oct. J Clin Neurosci.44:254-259. Epub 2017 Jul 12.
By:
  • Quick-Weller J
  • Tritt S
  • Behmanesh B
  • Mittelbronn M
  • Spyrantis A
  • Dinc N
  • Weise L
  • Seifert V
  • Marquardt G
  • Freiman TM.

Effects of soluble CPE on glioma cell migration are associated with mTOR activation and enhanced glucose flux.

  • Luxembourg Center of Neuropathology
September 15, 2017
2017 Sep. Oncotarget.8(40):67567-67591.
By:
  • Ilina EI
  • Armento A
  • Sanchez LG
  • Reichlmeir M
  • Braun Y
  • Penski C
  • Capper D
  • Sahm F
  • Jennewein L
  • Harter PN
  • Zukunft S
  • Fleming I
  • Schulte D
  • Le Guerroue F
  • Behrends C
  • Ronellenfitsch MW
  • Naumann U
  • Mittelbronn M.

Progression of pathology in PINK1-deficient mouse brain from splicing via ubiquitination, ER stress, and mitophagy changes to neuroinflammation.

  • Luxembourg Center of Neuropathology
August 02, 2017
2017 Aug. J Neuroinflammation.14(1):154.
By:
  • Torres-Odio S
  • Key J
  • Hoepken HH
  • Canet-Pons J
  • Valek L
  • Roller B
  • Walter M
  • Morales-Gordo B
  • Meierhofer D
  • Harter PN
  • Mittelbronn M
  • Tegeder I
  • Gispert S
  • Auburger G.

Carboxypeptidase E transmits its anti-migratory function in glioma cells via transcriptional regulation of cell architecture and motility regulating factors.

  • Luxembourg Center of Neuropathology
  • Bioinformatics and Modelling
  • Genomics Center
  • NORLUX-Glioma Biology
August 01, 2017
2017 Aug. Int J Oncol.51(2):702-714. Epub 2017 Jun 21.
By:
  • Armento A
  • Ilina EI
  • Kaoma T
  • Muller A
  • Vallar L
  • Niclou SP
  • Kruger MA
  • Mittelbronn M
  • Naumann U.

Long noncoding RNA MANTIS facilitates endothelial angiogenic function.

  • Luxembourg Center of Neuropathology
July 04, 2017
2017 Jul. Circulation.136(1):65-79. Epub 2017 Mar 28.
By:
  • Leisegang MS
  • Fork C
  • Josipovic I
  • Richter FM
  • Preussner J
  • Hu J
  • Miller MJ
  • Epah J
  • Hofmann P
  • Gunther S
  • Moll F
  • Valasarajan C
  • Heidler J
  • Ponomareva Y
  • Freiman TM
  • Maegdefessel L
  • Plate KH
  • Mittelbronn M
  • Uchida S
  • Kunne C
  • Stellos K
  • Schermuly RT
  • Weissmann N
  • Devraj K
  • Wittig I
  • Boon RA
  • Dimmeler S
  • Pullamsetti SS
  • Looso M
  • Miller FJ
  • Brandes RP.

Bevacizumab for patients with recurrent gliomas presenting with a gliomatosis cerebri growth pattern.

  • Luxembourg Center of Neuropathology
March 29, 2017
2017 Mar. Int J Mol Sci.18(4).
By:
  • Burger MC
  • Mildenberger IC
  • Wagner M
  • Mittelbronn M
  • Steinbach JP
  • Bahr O.