Guy Berchem

Latest publications

Targeting autophagy inhibits melanoma growth by enhancing NK cells infiltration in a CCL5-dependent manner.

  • Tumor Microenvironment
  • Tumor Stroma Interactions
  • National Cytometry Platform
October 31, 2017
2017 Oct. Proc Natl Acad Sci U S A.114(44):E9271-E9279. Epub 2017 Oct 16.
By:
  • Mgrditchian T
  • Arakelian T
  • Paggetti J
  • Noman MZ
  • Viry E
  • Moussay E
  • Van Moer K
  • Kreis S
  • Guerin C
  • Buart S
  • Robert C
  • Borg C
  • Vielh P
  • Chouaib S
  • Berchem G
  • Janji B.

Hijacker of the antitumor immune response: autophagy is showing its worst facet.

  • Tumor Microenvironment
  • Tumor Stroma Interactions
November 18, 2016
2016 Nov. Front Oncol.6(246).
By:
  • Viry E
  • Noman MZ
  • Arakelian T
  • Lequeux A
  • Chouaib S
  • Berchem G
  • Moussay E
  • Paggetti J
  • Janji B.

A high rate of telomeric sister chromatid exchange occurs in chronic lymphocytic leukaemia B-cells.

  • Tumor Stroma Interactions
  • Laboratory of Oncolytic-Virus-Immuno-Therapeutics
July 01, 2016
2016 Jul. Br J Haematol.174(1):57-70. Epub 2016 Mar 11.
By:
  • Medves S
  • Auchter M
  • Chambeau L
  • Gazzo S
  • Poncet D
  • Grangier B
  • Verney A
  • Moussay E
  • Ammerlaan W
  • Brisou G
  • Morjani H
  • Geli V
  • Palissot V
  • Berchem G
  • Salles G
  • Wenner T.

The multifaceted role of autophagy in tumor evasion from immune surveillance.

  • Tumor Microenvironment
  • Tumor Stroma Interactions
April 05, 2016
2016 Apr. Oncotarget.7(14):17591-607.
By:
  • Janji B
  • Viry E
  • Moussay E
  • Paggetti J
  • Arakelian T
  • Mgrditchian T
  • Messai Y
  • Noman MZ
  • Van Moer K
  • Hasmim M
  • Mami-Chouaib F
  • Berchem G
  • Chouaib S.

Hypoxic tumor-derived microvesicles negatively regulate NK cell function by a mechanism involving TGF-beta and miR23a transfer.

  • Tumor Microenvironment
  • Tumor Stroma Interactions
April 01, 2016
2016 Apr. OncoImmunology.5(4):e1062968. Epub 2015 Jun 24.
By:
  • Berchem G
  • Noman MZ
  • Bosseler M
  • Paggetti J
  • Baconnais S
  • Le Cam E
  • Nanbakhsh A
  • Moussay E
  • Mami-Chouaib F
  • Janji B
  • Chouaib S.

Autophagy Activation in the Tumor Microenvironment: A Major Process in Shaping the Antitumor Immune Response. In Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging. 1st ed. (Book Chapter)

  • Tumor Microenvironment
  • Tumor Stroma Interactions
February 25, 2016
2016 Feb. San Diego: Academic Press, 2016. p.267-290. (Vol. 8). ISBN 978-0-12-802937-4.
By:
  • Janji B
  • Viry E
  • Mgrditchian T
  • Arakelian T
  • Medves S
  • Berchem G.

Autophagy regulation of the tumor immunity: An old housekeeper for a new function. In Cell Death - Autophagy, Necrosis and Apoptosis. (Book Chapter)

  • Tumor Microenvironment
  • Tumor Stroma Interactions
December 16, 2015
2015 Dec. Ntuli DT, ed. Rijeka: InTech, 2015. p.37-61. ISBN 978-953-51-2236-4.
By:
  • Arakelian T
  • Mgrditchian T
  • Viry E
  • Van Moer K
  • Paggetti J
  • Berchem G
  • Chouaib S
  • Janji B.

Exosomes released by chronic lymphocytic leukemia cells induce the transition of stromal cells into cancer-associated fibroblasts.

  • Tumor Stroma Interactions
  • Tumor Microenvironment
  • Discovery Proteomics
  • Clinical Proteomics
August 27, 2015
2015 Aug. Blood.126(9):1106-17. Epub 2015 Jun 22.
By:
  • Paggetti J
  • Haderk F
  • Seiffert M
  • Janji B
  • Distler U
  • Ammerlaan W
  • Kim YJ
  • Adam J
  • Lichter P
  • Solary E
  • Berchem G
  • Moussay E.

Verification of the biomarker candidates for non-small-cell lung cancer using a targeted proteomics approach.

  • Clinical Proteomics
  • Tumor Stroma Interactions
  • Discovery Proteomics
March 06, 2015
2015 Mar. J Proteome Res.14(3):1412-9. Epub 2015 Feb 9.
By:
  • Kim YJ
  • Sertamo K
  • Pierrard MA
  • Mesmin C
  • Kim SY
  • Schlesser M
  • Berchem G
  • Domon B.

Hypoxia: A key feature of the tumor microenvironment triggers several mechanisms of evasion from natural killer and cytotoxic T lymphocytes surveillance.

  • Tumor Microenvironment
  • Tumor Stroma Interactions
  • Cytoskeleton and Cancer Progression
November 20, 2014
2014 Nov. J Imm Res.1(2):7.
By:
  • Mgrditchian T
  • Arakelian T
  • Paggetti J
  • Viry E
  • Al-Absi A
  • Medves S
  • Moussay E
  • Berchem G
  • Thomas C
  • Janji B.

Autophagy: An adaptive metabolic response to stress shaping the antitumor immunity.

  • Tumor Microenvironment
  • Tumor Stroma Interactions
November 01, 2014
2014 Nov. Biochem Pharmacol.92(1):31-42. Epub 2014 Jul 17.
By:
  • Viry E
  • Paggetti J
  • Baginska J
  • Mgrditchian T
  • Berchem G
  • Moussay E
  • Janji B.

Hypoxia-induced autophagy in tumor cells: a key target for improving cancer immunotherapy.

  • Tumor Stroma Interactions
  • Tumor Microenvironment
September 14, 2014
2014 Sep. Cancer Cell Microenviron.1(4):e213.
By:
  • Paggetti J
  • Viry E
  • Berchem G
  • Moussay E
  • Janji B.

Disruption of autophagy by the histone deacetylase inhibitor MGCD0103 and its therapeutic implication in B-Cell chronic lymphocytic leukemia.

  • Tumor Stroma Interactions
  • National Cytometry Platform
  • NORLUX-Glioma Biology
August 01, 2014
2014 Aug. Leukemia.28(8):1636-46. Epub 2014 Jan 14.
By:
  • El-Khoury V
  • Pierson S
  • Szwarcbart E
  • Brons NH
  • Roland O
  • Cherrier-De Wilde S
  • Plawny L
  • Van Dyck E
  • Berchem G.

Autophagic degradation of GZMB/granzyme B: a new mechanism of hypoxic tumor cell escape from natural killer cell-mediated lysis.

  • Tumor Microenvironment
  • Tumor Stroma Interactions
January 01, 2014
2014 Jan. Autophagy.10(1):173-5. Epub 2013 Nov 15.
By:
  • Viry E
  • Baginska J
  • Berchem G
  • Noman MZ
  • Medves S
  • Chouaib S
  • Janji B.

The Critical Role of the Tumor Microenvironment in Shaping Natural Killer Cell-Mediated Anti-Tumor Immunity.

  • Tumor Microenvironment
  • Tumor Stroma Interactions
December 01, 2013
2013 Dec. Front Immunol.4:490.
By:
  • Baginska J
  • Viry E
  • Paggetti J
  • Medves S
  • Berchem G
  • Moussay E
  • Janji B.

Stromal cell-induced miRNA alteration in chronic lymphocytic leukemia: how a minute and unavoidable cell contamination impairs miRNA profiling.

  • Tumor Stroma Interactions
August 01, 2013
2013 Aug. Leukemia.27(8):1773-6. Epub 2013 Feb 14.
By:
  • Paggetti J
  • Berchem G
  • Moussay E.

Blocking hypoxia-induced autophagy in tumors restores cytotoxic T cell activity and promotes regression.

  • Tumor Microenvironment
  • Tumor Stroma Interactions
September 15, 2011
2011 Sep. Cancer Res. Epub 2011 Aug 2.
By:
  • Noman MZ
  • Janji B
  • Kaminska B
  • Van Moer K
  • Pierson S
  • Przanowski P
  • Buart S
  • Berchem G
  • Romero P
  • Mami-Chouaib F
  • Chouaib S.

The acquisition of resistance to TNFalpha in breast cancer cells is associated with constitutive activation of autophagy as revealed by a transcriptome analysis using a custom microarray.

  • Tumor Stroma Interactions
  • Tumor Microenvironment
  • Genomics Center
July 01, 2011
2011 Jul. Autophagy.7(7):760-70. Epub 2011 Jul 1.
By:
  • Moussay E
  • Kaoma T
  • Baginska J
  • Muller A
  • Van Moer K
  • Nicot N
  • Nazarov PV
  • Vallar L
  • Chouaib S
  • Berchem G
  • Janji B.

MicroRNA as biomarkers and regulators in B-cell chronic lymphocytic leukemia.

  • Tumor Stroma Interactions
  • Tumor Microenvironment
  • Genomics Center
April 19, 2011
2011 Apr. Proc Natl Acad Sci U S A.108(16):6573-8. Epub 2011 Apr 1.
By:
  • Moussay E
  • Wang K
  • Cho JH
  • van Moer K
  • Pierson S
  • Paggetti J
  • Nazarov PV
  • Palissot V
  • Hood LE
  • Berchem G
  • Galas DJ.

Determination of genes and microRNAs involved in the resistance to fludarabine in vivo in chronic lymphocytic leukemia.

  • Tumor Stroma Interactions
  • Tumor Microenvironment
  • Genomics Center
May 01, 2010
2010 May. Mol Cancer.9(1):115. emoussay, vpalissot, lvallar, $, $, velkhoury, naouali, kvanmoer, bleners, fbernardin, .amuller, $, $, $, $, evandyck, gberchem.
By:
  • Moussay E
  • Palissot V
  • Vallar L
  • Poirel HA
  • Wenner T
  • El-Khoury V
  • Aouali N
  • van Moer K
  • Leners B
  • Bernardin F
  • Muller A
  • Cornillet-Lefebvre P
  • Delmer A
  • Duhem C
  • Ries F
  • van Dyck E
  • Berchem G.