Olivier Keunen

Latest publications

Altered metabolic landscape in IDH-mutant gliomas affects phospholipid, energy, and oxidative stress pathways.

  • NORLUX-Glioma Biology
  • In vivo imaging facility
  • Bioinformatics and Modelling
October 20, 2017
2017 Oct. EMBO Mol Med. [Epub ahead of print].
By:
  • Fack F
  • Tardito S
  • Hochart G
  • Oudin A
  • Zheng L
  • Fritah S
  • Golebiewska A
  • Nazarov PV
  • Bernard A
  • Hau AC
  • Keunen O
  • Leenders W
  • Lund-Johansen M
  • Stauber J
  • Gottlieb E
  • Bjerkvig R
  • Niclou SP.

Lack of functional normalisation of tumour vessels following anti-angiogenic therapy in glioblastoma.

  • NORLUX-Glioma Biology
  • In vivo imaging facility
January 01, 2017
2017 Jan. J Cereb Blood Flow Metab.271678X17714656. [Epub ahead of print].
By:
  • Obad N
  • Espedal H
  • Jirik R
  • Sakariassen PO
  • Brekke Rygh C
  • Lund-Johansen M
  • Taxt T
  • Niclou SP
  • Bjerkvig R
  • Keunen O.

EGFRvIII mutations can emerge as late and heterogenous events in glioblastoma development and promote angiogenesis through Src activation.

  • NORLUX-Glioma Biology
  • In vivo imaging facility
December 01, 2016
2016 Dec. Neuro Oncol.18(12):1644-1655. Epub 2016 Jun 10.
By:
  • Eskilsson E
  • Rosland GV
  • Talasila KM
  • Knappskog S
  • Keunen O
  • Sottoriva A
  • Foerster S
  • Solecki G
  • Taxt T
  • Jirik R
  • Fritah S
  • Harter PN
  • Valk K
  • Al Hossain J
  • Joseph JV
  • Jahedi R
  • Saed HS
  • Piccirillo SG
  • Spiteri I
  • Leiss L
  • Euskirchen P
  • Graziani G
  • Daubon T
  • Lund-Johansen M
  • Enger PO
  • Winkler F
  • Ritter CA
  • Niclou SP
  • Watts C
  • Bjerkvig R
  • Miletic H.

Molecular crosstalk between tumour and brain parenchyma instructs histopathological features in glioblastoma.

  • NORLUX-Glioma Biology
  • In vivo imaging facility
  • Bioinformatics and Modelling
  • Genomics Center
  • National Cytometry Platform
May 31, 2016
2016 May. Oncotarget.7(22):31955-71.
By:
  • Bougnaud S
  • Golebiewska A
  • Oudin A
  • Keunen O
  • Harter PN
  • Mader L
  • Azuaje F
  • Fritah S
  • Stieber D
  • Kaoma T
  • Vallar L
  • Brons NH
  • Daubon T
  • Miletic H
  • Sundstrom T
  • Herold-Mende C
  • Mittelbronn M
  • Bjerkvig R
  • Niclou SP.

Glutamine synthetase activity fuels nucleotide biosynthesis and supports growth of glutamine-restricted glioblastoma.

  • NORLUX-Glioma Biology
  • In vivo imaging facility
December 01, 2015
2015 Dec. Nat Cell Biol.17(12):1556-68. Epub 2015 Nov 23.
By:
  • Tardito S
  • Oudin A
  • Ahmed SU
  • Fack F
  • Keunen O
  • Zheng L
  • Miletic H
  • Sakariassen PO
  • Weinstock A
  • Wagner A
  • Lindsay SL
  • Hock AK
  • Barnett SC
  • Ruppin E
  • Morkve SH
  • Lund-Johansen M
  • Chalmers AJ
  • Bjerkvig R
  • Niclou SP
  • Gottlieb E.

Bevacizumab treatment induces metabolic adaptation toward anaerobic metabolism in glioblastomas.

  • NORLUX-Glioma Biology
  • In vivo imaging facility
January 01, 2015
2015 Jan. Acta Neuropathol.129(1):115-31. Epub 2014 Oct 17.
By:
  • Fack F
  • Espedal H
  • Keunen O
  • Golebiewska A
  • Obad N
  • Harter PN
  • Mittelbronn M
  • Bahr O
  • Weyerbrock A
  • Stuhr L
  • Miletic H
  • Sakariassen PO
  • Stieber D
  • Rygh CB
  • Lund-Johansen M
  • Zheng L
  • Gottlieb E
  • Niclou SP
  • Bjerkvig R.

Multimodal imaging of physiologic changes induced by anti-angiogenic therapy in glioblastoma. (Doctoral thesis)

  • NORLUX-Glioma Biology
December 18, 2014
2014 Dec. Bergen: University of Bergen, 2014. 56 (+ References) p.
By:
  • Keunen O.

Multimodal imaging of gliomas in the context of evolving cellular and molecular therapies.

  • NORLUX-Glioma Biology
September 30, 2014
2014 Sep. Adv Drug Deliv Rev.76:98-115. Epub 2014 Jul 28.
By:
  • Keunen O
  • Taxt T
  • Gruner R
  • Lund-Johansen M
  • Tonn JC
  • Pavlin T
  • Bjerkvig R
  • Niclou SP
  • Thorsen F.

Bevacizumab treatment for human glioblastoma. Can it induce cognitive impairment?

  • NORLUX-Glioma Biology
May 01, 2014
2014 May. Neuro Oncol.16(5):754-6.
By:
  • Pakzad A
  • Obad N
  • Espedal H
  • Stieber D
  • Keunen O
  • Sakariassen PO
  • Niclou SP
  • Bjerkvig R.

The soluble form of the tumor suppressor Lrig1 potently inhibits in vivo glioma growth irrespective of EGF receptor status.

  • NORLUX-Glioma Biology
September 01, 2013
2013 Sep. Neuro Oncol.15(9):1200-11. Epub 2013 May 30.
By:
  • Johansson M
  • Oudin A
  • Tiemann K
  • Bernard A
  • Golebiewska A
  • Keunen O
  • Fack F
  • Stieber D
  • Wang B
  • Hedman H
  • Niclou SP.

EGFR wild-type amplification and activation promote invasion and development of glioblastoma independent of angiogenesis.

  • NORLUX-Glioma Biology
May 01, 2013
2013 May. Acta Neuropathol.125(5):683-98. Epub 2013 Feb 22.
By:
  • Talasila KM
  • Soentgerath A
  • Euskirchen P
  • Rosland GV
  • Wang J
  • Huszthy PC
  • Prestegarden L
  • Skaftnesmo KO
  • Sakariassen PO
  • Eskilsson E
  • Stieber D
  • Keunen O
  • Brekka N
  • Moen I
  • Nigro JM
  • Vintermyr OK
  • Lund-Johansen M
  • Niclou S
  • Mork SJ
  • Enger PO
  • Bjerkvig R
  • Miletic H.

Anti-VEGF treatment reduces blood supply and increases tumor cell invasion in glioblastoma.

  • NORLUX-Glioma Biology
March 01, 2011
2011 Mar. Proc Natl Acad Sci U S A.108(9):3749-54. Epub 2011 Feb 14.
By:
  • Keunen O
  • Johansson M
  • Oudin A
  • Sanzey M
  • Rahim SA
  • Fack F
  • Thorsen F
  • Taxt T
  • Bartos M
  • Jirik R
  • Miletic H
  • Wang J
  • Stieber D
  • Stuhr L
  • Moen I
  • Rygh CB
  • Bjerkvig R
  • Niclou SP.