Simone Niclou

Latest publications

Single-cell transcriptomics reveals distinct inflammation-induced microglia signatures.

  • NORLUX-Glioma Biology
  • Bioinformatics and Modelling
September 11, 2018
2018 Sep. EMBO Rep. [Epub ahead of print].
By:
  • Sousa C
  • Golebiewska A
  • Poovathingal SK
  • Kaoma T
  • Pires-Afonso Y
  • Martina S
  • Coowar D
  • Azuaje F
  • Skupin A
  • Balling R
  • Biber K
  • Niclou SP
  • Michelucci A.

EGFL7 enhances surface expression of integrin alpha5beta1 to promote angiogenesis in malignant brain tumors.

  • NORLUX-Glioma Biology
  • In vivo imaging facility
  • Luxembourg Center of Neuropathology
September 01, 2018
2018 Sep. EMBO Mol Med.10(9).
By:
  • Dudvarski Stankovic N
  • Bicker F
  • Keller S
  • Jones DT
  • Harter PN
  • Kienzle A
  • Gillmann C
  • Arnold P
  • Golebiewska A
  • Keunen O
  • Giese A
  • von Deimling A
  • Bauerle T
  • Niclou SP
  • Mittelbronn M
  • Ye W
  • Pfister SM
  • Schmidt MH.

RNAi/CRISPR Screens: from a Pool to a Valid Hit.

  • NORLUX-Glioma Biology
  • Bioinformatics and Modelling
August 31, 2018
2018 Aug. Trends Biotechnol. [Epub ahead of print].
By:
  • Schuster A
  • Erasimus H
  • Fritah S
  • Nazarov PV
  • van Dyck E
  • Niclou SP
  • Golebiewska A.

Revival of the VEGF ligand family?

  • NORLUX-Glioma Biology
August 21, 2018
2018 Aug. Neuro Oncol. [Epub ahead of print].
By:
  • Niclou SP.

Investigation of IDH-mutant Gliomas Metabolism by Mass Spectrometry Imaging (Application Note #MSI-16)

  • NORLUX-Glioma Biology
June 25, 2018
2018 Jun. Imabiotech, 2018. 4 p.
By:
  • Hochart G
  • Fack F
  • Tardito S
  • Stauber J
  • Fontaine E
  • Niclou S
  • Stauber J.

Glioma through the looking GLASS: Molecular evolution of diffuse gliomas and the Glioma Longitudinal AnalySiS Consortium.

  • NORLUX-Glioma Biology
June 18, 2018
2018 Jun. Neuro Oncol.20(7):873-884.
By:
  • Aldape K
  • Amin SB
  • Ashley DM
  • Barnholtz-Sloan JS
  • Bates AJ
  • Beroukhim R
  • Bock C
  • Brat DJ
  • Claus EB
  • Costello JF
  • de Groot JF
  • Finocchiaro G
  • French PJ
  • Gan HK
  • Griffith B
  • Herold-Mende CC
  • Horbinski C
  • Iavarone A
  • Kalkanis SN
  • Karabatsou K
  • Kim H
  • Kouwenhoven MCM
  • McDonald KL
  • Miletic H
  • Nam DH
  • Ng HK
  • Niclou SP
  • Noushmehr H
  • Ormond R
  • Poisson LM
  • Reifenberger G
  • Roncaroli F
  • Sa JK
  • Sillevis Smitt PAE
  • Smits M
  • Souza CF
  • Tabatabai G
  • Van Meir EG
  • Verhaak RGW
  • Watts C
  • Wesseling P
  • Woehrer A
  • Yung WKA
  • Jungk C
  • Hau AC
  • van Dyck E
  • Westerman BA
  • Yin J
  • Abiola O
  • Zeps N
  • Grimmond S
  • Buckland M
  • Khasraw M
  • Sulman EP
  • Muscat AM
  • Stead L
  • Glass Consortium.

Pericytes/vessel-associated mural cells (VAMCs) are the major source of key epithelial-mesenchymal transition (EMT) factors SLUG and TWIST in human glioma.

  • Luxembourg Center of Neuropathology
  • NORLUX-Glioma Biology
May 08, 2018
2018 May. Oncotarget.9(35):24041-24053.
By:
  • Mader L
  • Blank AE
  • Capper D
  • Jansong J
  • Baumgarten P
  • Wirsik NM
  • Zachskorn C
  • Ehlers J
  • Seifert M
  • Klink B
  • Liebner S
  • Niclou S
  • Naumann U
  • Harter PN
  • Mittelbronn M.

Increased formate overflow is a hallmark of oxidative cancer.

  • NORLUX-Glioma Biology
April 10, 2018
2018 Apr. Nat Commun.9(1):1368.
By:
  • Meiser J
  • Schuster A
  • Pietzke M
  • Vande Voorde J
  • Athineos D
  • Oizel K
  • Burgos-Barragan G
  • Wit N
  • Dhayade S
  • Morton JP
  • Dornier E
  • Sumpton D
  • Mackay GM
  • Blyth K
  • Patel KJ
  • Niclou SP
  • Vazquez A.

Dual PD1/LAG3 immune checkpoint blockade limits tumor development in a murine model of chronic lymphocytic leukemia.

  • Tumor Stroma Interactions
  • National Cytometry Platform
  • Tumor Microenvironment
  • NORLUX-Glioma Biology
  • Allergy and Clinical Immunology
April 05, 2018
2018 Apr. Blood.131(14):1617-1621. Epub 2018 Feb 13.
By:
  • Wierz M
  • Pierson S
  • Guyonnet L
  • Viry E
  • Lequeux A
  • Oudin A
  • Niclou SP
  • Ollert M
  • Berchem G
  • Janji B
  • Guerin C
  • Paggetti J
  • Moussay E.

Altered metabolic landscape in IDH-mutant gliomas affects phospholipid, energy, and oxidative stress pathways.

  • NORLUX-Glioma Biology
  • In vivo imaging facility
  • Bioinformatics and Modelling
December 01, 2017
2017 Dec. EMBO Mol Med.9(12):1681-1695.
By:
  • Fack F
  • Tardito S
  • Hochart G
  • Oudin A
  • Zheng L
  • Fritah S
  • Golebiewska A
  • Nazarov PV
  • Bernard A
  • Hau AC
  • Keunen O
  • Leenders W
  • Lund-Johansen M
  • Stauber J
  • Gottlieb E
  • Bjerkvig R
  • Niclou SP.

Regulation of hypoxia-induced autophagy in glioblastoma involves ATG9A.

  • NORLUX-Glioma Biology
  • Animal Facility
  • Bioinformatics and Modelling
  • Genomics Center
  • Tumor Microenvironment
September 05, 2017
2017 Sep. Br J Cancer.117(6):813-825. Epub 2017 Aug 10.
By:
  • Abdul Rahim SA
  • Dirkse A
  • Oudin A
  • Schuster A
  • Bohler J
  • Barthelemy V
  • Muller A
  • Vallar L
  • Janji B
  • Golebiewska A
  • Niclou SP.

Carboxypeptidase E transmits its anti-migratory function in glioma cells via transcriptional regulation of cell architecture and motility regulating factors.

  • Luxembourg Center of Neuropathology
  • Bioinformatics and Modelling
  • Genomics Center
  • NORLUX-Glioma Biology
August 01, 2017
2017 Aug. Int J Oncol.51(2):702-714. Epub 2017 Jun 21.
By:
  • Armento A
  • Ilina EI
  • Kaoma T
  • Muller A
  • Vallar L
  • Niclou SP
  • Kruger MA
  • Mittelbronn M
  • Naumann U.

Harnessing LRIG1-mediated inhibition of receptor tyrosine kinases for cancer therapy.

  • NORLUX-Glioma Biology
August 01, 2017
2017 Aug. Biochim Biophys Acta-Rev Cancer.1868(1):109-116. Epub 2017 Mar 1.
By:
  • Neirinckx V
  • Hedman H
  • Niclou SP.

Aptamer functionalization of nanosystems for glioblastoma targeting through the blood-brain barrier.

  • NORLUX-Glioma Biology
May 25, 2017
2017 May. J Med Chem.60(10):4510-4516. Epub 2017 May 10.
By:
  • Monaco I
  • Camorani S
  • Colecchia D
  • Locatelli E
  • Calandro P
  • Oudin A
  • Niclou S
  • Arra C
  • Chiariello M
  • Cerchia L
  • Comes Franchini M.

The angiogenic switch leads to a metabolic shift in human glioblastoma.

  • NORLUX-Glioma Biology
  • Bioinformatics and Modelling
  • Genomics Center
March 01, 2017
2017 Mar. Neuro Oncol.19(3):383-393.
By:
  • Talasila KM
  • Rosland GV
  • Hagland HR
  • Eskilsson E
  • Flones IH
  • Fritah S
  • Azuaje F
  • Atai N
  • Harter PN
  • Mittelbronn M
  • Andersen M
  • Joseph JV
  • Hossain JA
  • Vallar L
  • Noorden CJ
  • Niclou SP
  • Thorsen F
  • Tronstad KJ
  • Tzoulis C
  • Bjerkvig R
  • Miletic H.

Lack of functional normalisation of tumour vessels following anti-angiogenic therapy in glioblastoma.

  • NORLUX-Glioma Biology
  • In vivo imaging facility
January 01, 2017
2017 Jan. J Cereb Blood Flow Metab.271678X17714656. [Epub ahead of print].
By:
  • Obad N
  • Espedal H
  • Jirik R
  • Sakariassen PO
  • Brekke Rygh C
  • Lund-Johansen M
  • Taxt T
  • Niclou SP
  • Bjerkvig R
  • Keunen O.

EGFRvIII mutations can emerge as late and heterogenous events in glioblastoma development and promote angiogenesis through Src activation.

  • NORLUX-Glioma Biology
  • In vivo imaging facility
December 01, 2016
2016 Dec. Neuro Oncol.18(12):1644-1655. Epub 2016 Jun 10.
By:
  • Eskilsson E
  • Rosland GV
  • Talasila KM
  • Knappskog S
  • Keunen O
  • Sottoriva A
  • Foerster S
  • Solecki G
  • Taxt T
  • Jirik R
  • Fritah S
  • Harter PN
  • Valk K
  • Al Hossain J
  • Joseph JV
  • Jahedi R
  • Saed HS
  • Piccirillo SG
  • Spiteri I
  • Leiss L
  • Euskirchen P
  • Graziani G
  • Daubon T
  • Lund-Johansen M
  • Enger PO
  • Winkler F
  • Ritter CA
  • Niclou SP
  • Watts C
  • Bjerkvig R
  • Miletic H.

Combined VEGFR and CTLA-4 blockade increases the antigen-presenting function of intratumoral DCs and reduces the suppressive capacity of intratumoral MDSCs.

  • NORLUX-Glioma Biology
November 01, 2016
2016 Nov. Am J Cancer Res.6(11):2514-2531.
By:
  • Du Four S
  • Maenhout SK
  • Niclou SP
  • Thielemans K
  • Neyns B
  • Aerts JL.

DNA repair mechanisms and their clinical impact in glioblastoma.

  • NORLUX-DNA repair and chemoresistance
  • NORLUX-Glioma Biology
June 21, 2016
2016 Jun. Mutat Res Rev Mutat Res.769:19-35. Epub 2016 Jun 21.
By:
  • Erasimus H
  • Gobin M
  • Niclou S
  • Van Dyck E.

Analysis of the dynamic co-expression network of heart regeneration in the zebrafish.

  • Bioinformatics and Modelling
  • Genomics Center
  • Clinical Proteomics
  • NORLUX-Glioma Biology
May 31, 2016
2016 May. Sci Rep.6:26822.
By:
  • Rodius S
  • Androsova G
  • Gotz L
  • Liechti R
  • Crespo I
  • Merz S
  • Nazarov PV
  • de Klein N
  • Jeanty C
  • Gonzalez-Rosa JM
  • Muller A
  • Bernardin F
  • Niclou SP
  • Vallar L
  • Mercader N
  • Ibberson M
  • Xenarios I
  • Azuaje F.