Simone Niclou

Latest publications

Altered metabolic landscape in IDH-mutant gliomas affects phospholipid, energy, and oxidative stress pathways.

  • NORLUX-Glioma Biology
  • In vivo imaging facility
  • Bioinformatics and Modelling
October 20, 2017
2017 Oct. EMBO Mol Med. [Epub ahead of print].
By:
  • Fack F
  • Tardito S
  • Hochart G
  • Oudin A
  • Zheng L
  • Fritah S
  • Golebiewska A
  • Nazarov PV
  • Bernard A
  • Hau AC
  • Keunen O
  • Leenders W
  • Lund-Johansen M
  • Stauber J
  • Gottlieb E
  • Bjerkvig R
  • Niclou SP.

Regulation of hypoxia-induced autophagy in glioblastoma involves ATG9A.

  • NORLUX-Glioma Biology
  • Animal Facility
  • Bioinformatics and Modelling
  • Genomics Center
  • Tumor Microenvironment
September 05, 2017
2017 Sep. Br J Cancer.117(6):813-825. Epub 2017 Aug 10.
By:
  • Abdul Rahim SA
  • Dirkse A
  • Oudin A
  • Schuster A
  • Bohler J
  • Barthelemy V
  • Muller A
  • Vallar L
  • Janji B
  • Golebiewska A
  • Niclou SP.

Carboxypeptidase E transmits its anti-migratory function in glioma cells via transcriptional regulation of cell architecture and motility regulating factors.

  • Luxembourg Center of Neuropathology
  • Bioinformatics and Modelling
  • Genomics Center
  • NORLUX-Glioma Biology
August 01, 2017
2017 Aug. Int J Oncol.51(2):702-714. Epub 2017 Jun 21.
By:
  • Armento A
  • Ilina EI
  • Kaoma T
  • Muller A
  • Vallar L
  • Niclou SP
  • Kruger MA
  • Mittelbronn M
  • Naumann U.

Harnessing LRIG1-mediated inhibition of receptor tyrosine kinases for cancer therapy.

  • NORLUX-Glioma Biology
August 01, 2017
2017 Aug. Biochim Biophys Acta-Rev Cancer.1868(1):109-116. Epub 2017 Mar 1.
By:
  • Neirinckx V
  • Hedman H
  • Niclou SP.

Aptamer functionalization of nanosystems for glioblastoma targeting through the blood-brain barrier.

  • NORLUX-Glioma Biology
May 25, 2017
2017 May. J Med Chem.60(10):4510-4516. Epub 2017 May 10.
By:
  • Monaco I
  • Camorani S
  • Colecchia D
  • Locatelli E
  • Calandro P
  • Oudin A
  • Niclou S
  • Arra C
  • Chiariello M
  • Cerchia L
  • Comes Franchini M.

The angiogenic switch leads to a metabolic shift in human glioblastoma.

  • NORLUX-Glioma Biology
  • Bioinformatics and Modelling
  • Genomics Center
March 01, 2017
2017 Mar. Neuro Oncol.19(3):383-393.
By:
  • Talasila KM
  • Rosland GV
  • Hagland HR
  • Eskilsson E
  • Flones IH
  • Fritah S
  • Azuaje F
  • Atai N
  • Harter PN
  • Mittelbronn M
  • Andersen M
  • Joseph JV
  • Hossain JA
  • Vallar L
  • Noorden CJ
  • Niclou SP
  • Thorsen F
  • Tronstad KJ
  • Tzoulis C
  • Bjerkvig R
  • Miletic H.

Lack of functional normalisation of tumour vessels following anti-angiogenic therapy in glioblastoma.

  • NORLUX-Glioma Biology
  • In vivo imaging facility
January 01, 2017
2017 Jan. J Cereb Blood Flow Metab.271678X17714656. [Epub ahead of print].
By:
  • Obad N
  • Espedal H
  • Jirik R
  • Sakariassen PO
  • Brekke Rygh C
  • Lund-Johansen M
  • Taxt T
  • Niclou SP
  • Bjerkvig R
  • Keunen O.

EGFRvIII mutations can emerge as late and heterogenous events in glioblastoma development and promote angiogenesis through Src activation.

  • NORLUX-Glioma Biology
  • In vivo imaging facility
December 01, 2016
2016 Dec. Neuro Oncol.18(12):1644-1655. Epub 2016 Jun 10.
By:
  • Eskilsson E
  • Rosland GV
  • Talasila KM
  • Knappskog S
  • Keunen O
  • Sottoriva A
  • Foerster S
  • Solecki G
  • Taxt T
  • Jirik R
  • Fritah S
  • Harter PN
  • Valk K
  • Al Hossain J
  • Joseph JV
  • Jahedi R
  • Saed HS
  • Piccirillo SG
  • Spiteri I
  • Leiss L
  • Euskirchen P
  • Graziani G
  • Daubon T
  • Lund-Johansen M
  • Enger PO
  • Winkler F
  • Ritter CA
  • Niclou SP
  • Watts C
  • Bjerkvig R
  • Miletic H.

Combined VEGFR and CTLA-4 blockade increases the antigen-presenting function of intratumoral DCs and reduces the suppressive capacity of intratumoral MDSCs.

  • NORLUX-Glioma Biology
November 01, 2016
2016 Nov. Am J Cancer Res.6(11):2514-2531.
By:
  • Du Four S
  • Maenhout SK
  • Niclou SP
  • Thielemans K
  • Neyns B
  • Aerts JL.

DNA repair mechanisms and their clinical impact in glioblastoma.

  • NORLUX-DNA repair and chemoresistance
  • NORLUX-Glioma Biology
June 21, 2016
2016 Jun. Mutat Res Rev Mutat Res.769:19-35. Epub 2016 Jun 21.
By:
  • Erasimus H
  • Gobin M
  • Niclou S
  • Van Dyck E.

Analysis of the dynamic co-expression network of heart regeneration in the zebrafish.

  • Bioinformatics and Modelling
  • Genomics Center
  • Clinical Proteomics
  • NORLUX-Glioma Biology
May 31, 2016
2016 May. Sci Rep.6:26822.
By:
  • Rodius S
  • Androsova G
  • Gotz L
  • Liechti R
  • Crespo I
  • Merz S
  • Nazarov PV
  • de Klein N
  • Jeanty C
  • Gonzalez-Rosa JM
  • Muller A
  • Bernardin F
  • Niclou SP
  • Vallar L
  • Mercader N
  • Ibberson M
  • Xenarios I
  • Azuaje F.

Molecular crosstalk between tumour and brain parenchyma instructs histopathological features in glioblastoma.

  • NORLUX-Glioma Biology
  • In vivo imaging facility
  • Bioinformatics and Modelling
  • Genomics Center
  • National Cytometry Platform
May 31, 2016
2016 May. Oncotarget.7(22):31955-71.
By:
  • Bougnaud S
  • Golebiewska A
  • Oudin A
  • Keunen O
  • Harter PN
  • Mader L
  • Azuaje F
  • Fritah S
  • Stieber D
  • Kaoma T
  • Vallar L
  • Brons NH
  • Daubon T
  • Miletic H
  • Sundstrom T
  • Herold-Mende C
  • Mittelbronn M
  • Bjerkvig R
  • Niclou SP.

Targeted proteomics to assess the response to anti-angiogenic treatment in human glioblastoma (GBM).

  • NORLUX-Glioma Biology
  • Discovery Proteomics
February 01, 2016
2016 Feb. Mol Cell Proteomics.15(2):481-92. Epub 2015 Aug 4.
By:
  • Demeure K
  • Fack F
  • Duriez E
  • Tiemann K
  • Bernard A
  • Golebiewska A
  • Bougnaud S
  • Bjerkvig R
  • Domon B
  • Niclou SP.

Glutamine synthetase activity fuels nucleotide biosynthesis and supports growth of glutamine-restricted glioblastoma.

  • NORLUX-Glioma Biology
  • In vivo imaging facility
December 01, 2015
2015 Dec. Nat Cell Biol.17(12):1556-68. Epub 2015 Nov 23.
By:
  • Tardito S
  • Oudin A
  • Ahmed SU
  • Fack F
  • Keunen O
  • Zheng L
  • Miletic H
  • Sakariassen PO
  • Weinstock A
  • Wagner A
  • Lindsay SL
  • Hock AK
  • Barnett SC
  • Ruppin E
  • Morkve SH
  • Lund-Johansen M
  • Chalmers AJ
  • Bjerkvig R
  • Niclou SP
  • Gottlieb E.

Intercellular transfer of transferrin receptor by a contact-, Rab8-dependent mechanism involving tunneling nanotubes.

  • NORLUX-Glioma Biology
November 01, 2015
2015 Nov. FASEB J.29(11):4695-712. Epub 2015 Jul 28.
By:
  • Burtey A
  • Wagner M
  • Hodneland E
  • Skaftnesmo KO
  • Schoelermann J
  • Mondragon IR
  • Espedal H
  • Golebiewska A
  • Niclou SP
  • Bjerkvig R
  • Kogel T
  • Gerdes HH.

Gauging heterogeneity in primary versus recurrent glioblastoma.

  • NORLUX-Glioma Biology
July 01, 2015
2015 Jul. Neuro Oncol.17(7):907-9. Epub 2015 May 12.
By:
  • Niclou SP.

Comprehensive analysis of glycolytic enzymes as therapeutic targets in the treatment of glioblastoma.

  • NORLUX-Glioma Biology
  • Genomics Center
May 01, 2015
2015 May. PLoS One.10(5):e0123544.
By:
  • Sanzey M
  • Abdul Rahim SA
  • Oudin A
  • Dirkse A
  • Kaoma T
  • Vallar L
  • Herold-Mende C
  • Bjerkvig R
  • Golebiewska A
  • Niclou SP.

Therapeutic control and resistance of the EGFR-driven signaling network in glioblastoma.

  • Bioinformatics and Modelling
  • NORLUX-Glioma Biology
March 31, 2015
2015 Mar. Cell Commun Signal.13(1):23.
By:
  • Azuaje F
  • Tiemann K
  • Niclou SP.

Whole genomes redefine the mutational landscape of pancreatic cancer.

  • NORLUX-Glioma Biology
February 25, 2015
2015 Feb. Nature.518(7540):495-501.
By:
  • Pajic M
  • Patch AM
  • Chang DK
  • Kassahn KS
  • Bailey P
  • Johns AL
  • Miller D
  • Nones K
  • Quek K
  • Quinn MC
  • Robertson AJ
  • Fadlullah MZ
  • Bruxner TJ
  • Christ AN
  • Harliwong I
  • Idrisoglu S
  • Manning S
  • Nourse C
  • Nourbakhsh E
  • Wani S
  • Wilson PJ
  • Markham E
  • Cloonan N
  • Anderson MJ
  • Fink JL
  • Holmes O
  • Kazakoff SH
  • Leonard C
  • Newell F
  • Poudel B
  • Song S
  • Taylor D
  • Waddell N
  • Wood S
  • Xu Q
  • Wu J
  • Pinese M
  • Cowley MJ
  • Lee HC
  • Jones MD
  • Nagrial AM
  • Humphris J
  • Chantrill LA
  • Chin V
  • Steinmann AM
  • Mawson A
  • Humphrey ES
  • Colvin EK
  • Chou A
  • Scarlett CJ
  • Pinho AV
  • Giry-Laterriere M
  • Rooman I
  • Samra JS
  • Kench JG
  • Pettitt JA
  • Merrett ND
  • Toon C
  • Epari K
  • Nguyen NQ
  • Barbour A
  • Zeps N
  • Jamieson NB
  • Graham JS
  • Niclou SP
  • Bjerkvig R
  • Grutzmann R
  • Aust D
  • Hruban RH
  • Maitra A
  • Iacobuzio-Donahue CA
  • Wolfgang CL
  • Morgan RA
  • Lawlor RT
  • Corbo V
  • Bassi C
  • Falconi M
  • Zamboni G
  • Tortora G
  • Tempero MA
  • Gill AJ
  • Eshleman JR
  • Pilarsky C
  • Scarpa A
  • Musgrove EA
  • Pearson JV
  • Biankin AV
  • Grimmond SM.

Axitinib increases the infiltration of immune cells and reduces the suppressive capacity of monocytic MDSCs in an intracranial mouse melanoma model.

  • NORLUX-Glioma Biology
January 22, 2015
2015 Jan. OncoImmunology.4(4):e998107.
By:
  • Du Four S
  • Maenhout SK
  • De Pierre K
  • Renmans D
  • Niclou SP
  • Thielemans K
  • Neyns B
  • Aerts JL.