Activities

Beyond their role in preventing genetic instability and tumorigenesis, DNA repair and epigenetic mechanisms also contribute to the resistance of cancer cells to chemotherapeutic genotoxics. These mechanisms are responsible in great part for the failure of current anti-glioma therapies. Our research group is developing several approaches (including differential shRNA screens, multiplexed gene expression analyses and studies in xenograft animal models) to better understand the DNA repair and epigenetic factors that operate in glioblastoma and identify critical therapeutic targets to prevent chemoresistance.

A second line of investigation explores fundamental aspects of the mechanisms underlying centromere dynamics as well as heterochromatin expression in mammalian cells.

Close collaborators include Drs R. Golbrunner and M. Timmer (Uniklinik Köln), Drs F. Sholtes and D. Martin (CHU Liège) and Dr Y.G. Yang (Beijing Institute of Genomics).

Research projects

  • Identification of novel molecular targets for temozolomide-based therapies against glioblastoma: a comprehensive shRNA-based screen of DNA damage response factors.
  • Impact of DNA repair genes and associated miRNAs in GBM biology and resistance to temozolomide: study of TMZ-positive and TMZ-negative GBM cohorts.
  • Epigenetic factors mediating heat-shock-induced expression of heterochromatin in human cells.

Featured Publications

Temozolomide-induced RNA interactome uncovers novel lncRNA regulatory loops in glioblastoma.

  • NORLUX Neuro-Oncology Laboratory
  • Quantitative Biology Unit
  • DNA Repair and Chemoresistance
September 10, 2020
2020 Sep. Cancers.12(9).
By:
  • Fritah S
  • Muller A
  • Jiang W
  • Mitra R
  • Sarmini M
  • Dieterle M
  • Golebiewska A
  • Ye T
  • Van Dyck E
  • Herold-Mende C
  • Zhao Z
  • Azuaje F
  • Niclou SP.

A DNA repair and cell-cycle gene expression signature in primary and recurrent glioblastoma: prognostic value and clinical implications.

  • DNA Repair and Chemoresistance
  • Computational Biomedicine
  • NORLUX Neuro-Oncology Laboratory
March 15, 2019
2019 Mar. Cancer Res.79(6):1226-1238. Epub 2019 Jan 23.
By:
  • Gobin M
  • Nazarov PV
  • Warta R
  • Timmer M
  • Reifenberger G
  • Felsberg J
  • Vallar L
  • Chalmers AJ
  • Herold-Mende CC
  • Goldbrunner R
  • Niclou SP
  • Van Dyck E.
See all publications

Contacts

Eric Van Dyck

Ph.D.

84, rue Val Fleuri
L-1526Luxembourg
Luxembourg
Tel. : +352 26970-239